2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. (E)-4-Hydroxycrotonic acid

(E)-4-Hydroxycrotonic acid  (Synonyms: trans-4-Hydroxycrotonic acid; trans-γ-Hydroxycrotonic acid; T‐HCA)

Cat. No.: HY-100982 Purity: ≥98.0%
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Handling Instructions Technical Support

(E)-4-Hydroxycrotonic acid (T-HCA) is a high-affinity ligand for GHB binding sites, with a ki value of 1.1 μM. The introduction of diaryl substituents into (E)-4-Hydroxycrotonic acid significantly enhances its affinity for GHB binding sites, with ki values ranging from 0.023 to 0.075 μM. (E)-4-Hydroxycrotonic acid holds promise for optimizing GHB ligand structures and assisting in the development of effective three-dimensional pharmacophore models.

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(E)-4-Hydroxycrotonic acid Chemical Structure

(E)-4-Hydroxycrotonic acid Chemical Structure

CAS No. : 24587-49-3

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Based on 1 publication(s) in Google Scholar

(E)-4-Hydroxycrotonic acid Related Antibodies

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Description

(E)-4-Hydroxycrotonic acid (T-HCA) is a high-affinity ligand for GHB binding sites, with a ki value of 1.1 μM. The introduction of diaryl substituents into (E)-4-Hydroxycrotonic acid significantly enhances its affinity for GHB binding sites, with ki values ranging from 0.023 to 0.075 μM. (E)-4-Hydroxycrotonic acid holds promise for optimizing GHB ligand structures and assisting in the development of effective three-dimensional pharmacophore models[1].

Molecular Weight

102.09

Formula

C4H6O3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(O)/C=C/CO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 175 mg/mL (1714.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 9.7953 mL 48.9764 mL 97.9528 mL
5 mM 1.9591 mL 9.7953 mL 19.5906 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 9.7953 mL 48.9764 mL 97.9528 mL 244.8820 mL
5 mM 1.9591 mL 9.7953 mL 19.5906 mL 48.9764 mL
10 mM 0.9795 mL 4.8976 mL 9.7953 mL 24.4882 mL
15 mM 0.6530 mL 3.2651 mL 6.5302 mL 16.3255 mL
20 mM 0.4898 mL 2.4488 mL 4.8976 mL 12.2441 mL
25 mM 0.3918 mL 1.9591 mL 3.9181 mL 9.7953 mL
30 mM 0.3265 mL 1.6325 mL 3.2651 mL 8.1627 mL
40 mM 0.2449 mL 1.2244 mL 2.4488 mL 6.1220 mL
50 mM 0.1959 mL 0.9795 mL 1.9591 mL 4.8976 mL
60 mM 0.1633 mL 0.8163 mL 1.6325 mL 4.0814 mL
80 mM 0.1224 mL 0.6122 mL 1.2244 mL 3.0610 mL
100 mM 0.0980 mL 0.4898 mL 0.9795 mL 2.4488 mL
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(E)-4-Hydroxycrotonic acid Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(E)-4-Hydroxycrotonic acid24587-49-3trans-4-Hydroxycrotonic acid trans-γ-Hydroxycrotonic acid T‐HCAGABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorInhibitorinhibitorinhibit

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