2. Immunology/Inflammation
  3. CD38
  4. (E/Z)-CCR-11

(E/Z)-CCR-11 (Comp 12) is a selective CD38 inhibitor, with an IC50 of 20.8 μM against CD38 cyclase. (E/Z)-CCR-11 promotes increases in cellular NAD+ levels and interferon γ.

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(E/Z)-CCR-11 Chemical Structure

(E/Z)-CCR-11 Chemical Structure

CAS No. : 301687-87-6

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5 mg USD 260 In-stock
10 mg USD 420 In-stock
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(E/Z)-CCR-11 Related Antibodies

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Description

(E/Z)-CCR-11 (Comp 12) is a selective CD38 inhibitor, with an IC50 of 20.8 μM against CD38 cyclase. (E/Z)-CCR-11 promotes increases in cellular NAD+ levels and interferon γ[1].

Molecular Weight

355.35

Formula

C15H8F3NO2S2
CAS No.
Appearance

Solid

Color

Yellow to brown

SMILES

O=C1NC(S/C1=C\C2=CC=C(C3=CC(C(F)(F)F)=CC=C3)O2)=S
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (281.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8141 mL 14.0706 mL 28.1413 mL
5 mM 0.5628 mL 2.8141 mL 5.6283 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8141 mL 14.0706 mL 28.1413 mL 70.3532 mL
5 mM 0.5628 mL 2.8141 mL 5.6283 mL 14.0706 mL
10 mM 0.2814 mL 1.4071 mL 2.8141 mL 7.0353 mL
15 mM 0.1876 mL 0.9380 mL 1.8761 mL 4.6902 mL
20 mM 0.1407 mL 0.7035 mL 1.4071 mL 3.5177 mL
25 mM 0.1126 mL 0.5628 mL 1.1257 mL 2.8141 mL
30 mM 0.0938 mL 0.4690 mL 0.9380 mL 2.3451 mL
40 mM 0.0704 mL 0.3518 mL 0.7035 mL 1.7588 mL
50 mM 0.0563 mL 0.2814 mL 0.5628 mL 1.4071 mL
60 mM 0.0469 mL 0.2345 mL 0.4690 mL 1.1726 mL
80 mM 0.0352 mL 0.1759 mL 0.3518 mL 0.8794 mL
100 mM 0.0281 mL 0.1407 mL 0.2814 mL 0.7035 mL
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(E/Z)-CCR-11 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(E/Z)-CCR-11301687-87-6CD38NAD+ levelsinterferon γInhibitorinhibitorinhibit

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