Ebiratide  (Synonyms: HOE-427 free base)

Ebiratide (HOE-427 free base) is an ACTH 4-9 derivative, which acts directly on the central nervous system and exhibits memory-enhancing efficacy. Ebiratide enhances acetycholine (ACh) metabolism in rat brain^[1][2].

Ebiratide (0.1-30 μg/kg, s.c., single dose) exhibits neuroprotective efficacy in electoconvulsive shock and Scopolamine (HY-N0296)-induced memory impairment in mice model, exhibits anti-amnestic efficacy^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

996.23

C₄₈H₇₃N₁₁O₁₀S

105611-68-5

{Met(O2)}-Glu-His-Phe-{d-Lys}-{Phe-NH(CH2)8NH2}

{Met(O2)}-EHF-{d-Lys}-{Phe-NH(CH2)8NH2}

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Hock FJ, et al., Learning and memory processes of an ACTH4-9 analog (ebiratide; Hoe 427) in mice and rats. Peptides. 1988 May-Jun;9(3):575-81.   [Content Brief]

  [2]. G Wiemer, et al. Neurochemical effects of the synthetic ACTH4-9-analog Hoe 427 (Ebiratide) in rat brain. Peptides. 1988 Sep-Oct;9(5):1081-7.  [Content Brief]