2. Academic Validation
  3. Learning and memory processes of an ACTH4-9 analog (ebiratide; Hoe 427) in mice and rats

Learning and memory processes of an ACTH4-9 analog (ebiratide; Hoe 427) in mice and rats

  • Peptides. 1988 May-Jun;9(3):575-81. doi: 10.1016/0196-9781(88)90167-2.
F J Hock 1,  H J Gerhards,  G Wiemer,  P Usinger,  R Geiger
Affiliations

Affiliation

  • 1 HOECHST AG, Department of Pharmacology, Frankfurt/M, Federal Republic of Germany.
PMID: 2843833 DOI: 10.1016/0196-9781(88)90167-2
Abstract

These experiments investigated the effects of the new ACTH4-9 analog ebiratide (Hoe 427) [H-Met(O2)-Glu-His-Phe-D-Lys-Phe-NH-(CH2)8-NH2 X 3 CH3COOH] on memory processes in mice and rats in five training tasks. With all five training and testing procedures (inhibitory avoidance test with ECS- or scopolamine-induced amnesia, up-hill avoidance, one-way shuttle box avoidance and eight-arm radial maze) ebiratide was most effective in a dose range of 1-10 micrograms/kg SC.

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