2. GPCR/G Protein
  3. Guanylate Cyclase
  4. Ebselen oxide

Ebselen oxide, the selenone analogue of Ebselen, covalently modifies diguanylate cyclase (DGC) to inhibit c-di-GMP-receptor interactions and reduces DGC activity. Ebselen oxide also inhibits alginate production (IC50=14 μM) by Pseudomonas aeruginosa. Ebselen oxide inhibits HDAC1, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, and HDAC9 (IC50 ranging from 0.2 to 4.7 μM).

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Ebselen oxide Chemical Structure

Ebselen oxide Chemical Structure

CAS No. : 104473-83-8

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Ebselen oxide Related Antibodies

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Description

Ebselen oxide, the selenone analogue of Ebselen, covalently modifies diguanylate cyclase (DGC) to inhibit c-di-GMP-receptor interactions and reduces DGC activity. Ebselen oxide also inhibits alginate production (IC50=14 μM) by Pseudomonas aeruginosa. Ebselen oxide inhibits HDAC1, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, and HDAC9 (IC50 ranging from 0.2 to 4.7 μM)[1][2][3].

In Vitro

Ebselen oxide, is a covalent inhibitor of c-di-GMP allosteric binding to I-site containing proteins, diguanylate cyclase (DGC) activity[1].
Ebselen oxide inhibits diguanylate cyclase from synthesizing c-di-GMP. Ebselen oxide exhibits increased potency on HDAC8 (IC50=0.2 μM) in comparison with Ebselen[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ebselen oxide Related Antibodies
Molecular Weight

290.18

Formula

C13H9NO2Se
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=[Se]1N(C(C2=C1C=CC=C2)=O)C3=CC=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (17.23 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4461 mL 17.2307 mL 34.4614 mL
5 mM 0.6892 mL 3.4461 mL 6.8923 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation

Purity: ≥98.0%

SDS (251 KB)

COA (253 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4461 mL 17.2307 mL 34.4614 mL 86.1534 mL
5 mM 0.6892 mL 3.4461 mL 6.8923 mL 17.2307 mL
10 mM 0.3446 mL 1.7231 mL 3.4461 mL 8.6153 mL
15 mM 0.2297 mL 1.1487 mL 2.2974 mL 5.7436 mL
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Ebselen oxide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ebselen oxide104473-83-8Guanylate Cyclasecovalentc-di-GMPallostericdiguanylate cyclasealginate synthesisInhibitorinhibitorinhibit

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