2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR
  4. Edaglitazone

Edaglitazone is a potent, selective and orally active PPARγ agonist, with EC50s of 35.6 nM and 1053 nM for PPARα and PPARγ, respectively. Edaglitazone displays antiplatelet, antidiabetic and anti-hyperglycemic activity.

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Edaglitazone Chemical Structure

Edaglitazone Chemical Structure

CAS No. : 213411-83-7

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Based on 1 publication(s) in Google Scholar

Edaglitazone Related Antibodies

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Description

Edaglitazone is a potent, selective and orally active PPARγ agonist, with EC50s of 35.6 nM and 1053 nM for PPARα and PPARγ, respectively. Edaglitazone displays antiplatelet, antidiabetic and anti-hyperglycemic activity[1][2][3].

IC50 & Target[1]

PPARγ

35.6 nM (EC50)

PPARα

1053 nM (EC50)

In Vitro

Edaglitazone (3-16 μM; 5 min) inhibits the collagen (1.2 μg/mL)-induced platelet aggregation. Edaglitazone increases the intraplatelet levels of cAMP in a concentration dependent manner. Edaglitazone preventes the Collagen-induced intraplatelet levels of PPARγ decrease[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Edaglitazone Related Antibodies
In Vivo

Edaglitazone (4.4 mg/kg; p.o. daily for 10 days) enhances insulin sensitivity in obese rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

464.56

Formula

C24H20N2O4S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1=C(N=C(C2=CC=CC=C2)O1)CCOC3=CC=C(C4=C3C=CS4)CC(S5)C(NC5=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 30 mg/mL (64.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1526 mL 10.7629 mL 21.5257 mL
5 mM 0.4305 mL 2.1526 mL 4.3051 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1526 mL 10.7629 mL 21.5257 mL 53.8144 mL
5 mM 0.4305 mL 2.1526 mL 4.3051 mL 10.7629 mL
10 mM 0.2153 mL 1.0763 mL 2.1526 mL 5.3814 mL
15 mM 0.1435 mL 0.7175 mL 1.4350 mL 3.5876 mL
20 mM 0.1076 mL 0.5381 mL 1.0763 mL 2.6907 mL
25 mM 0.0861 mL 0.4305 mL 0.8610 mL 2.1526 mL
30 mM 0.0718 mL 0.3588 mL 0.7175 mL 1.7938 mL
40 mM 0.0538 mL 0.2691 mL 0.5381 mL 1.3454 mL
50 mM 0.0431 mL 0.2153 mL 0.4305 mL 1.0763 mL
60 mM 0.0359 mL 0.1794 mL 0.3588 mL 0.8969 mL
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Edaglitazone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Edaglitazone213411-83-7PPARPeroxisome proliferator-activated receptorsantiplateletantidiabeticanti-hyperglycemicInhibitorinhibitorinhibit

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