2. Anti-infection
  3. HIV Reverse Transcriptase
  4. EFdA-TP tetralithium

EFdA-TP tetralithium is a potent nucleoside reverse transcriptase (RT) inhibitor. EFdA-TP tetralithium inhibits RT-catalyzed DNA synthesis as an effective immediate or delayed chain terminator (ICT or DCT). EFdA-TP tetralithium inhibits HIV-1 RT with multiple mechanisms.

For research use only. We do not sell to patients.

EFdA-TP tetralithium Chemical Structure

EFdA-TP tetralithium Chemical Structure

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1 mg USD 780 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of EFdA-TP tetralithium:

EFdA-TP tetralithium Related Antibodies

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Description

EFdA-TP tetralithium is a potent nucleoside reverse transcriptase (RT) inhibitor. EFdA-TP tetralithium inhibits RT-catalyzed DNA synthesis as an effective immediate or delayed chain terminator (ICT or DCT). EFdA-TP tetralithium inhibits HIV-1 RT with multiple mechanisms[1].

In Vitro

EFdA-TP (0.05-10 μM; for 15 min) tetralithium inhibits RT-catalyzed DNA synthesis as an ICT or DCT[1].
EFdA-TP tetralithium can block RT as a translocation-defective RT inhibitor that dramatically slows DNA synthesis, acting as a de facto immediate chain terminator[1].
EFdA-TP tetralithium can function as a delayed chain terminator, allowing incorporation of an additional dNTP before blocking DNA synthesis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

EFdA-TP tetralithium Related Antibodies
Molecular Weight

559.95

Formula

C12H14FLi4N5O12P3
Appearance

Solid

Color

White to off-white

SMILES

O=[P](O[P](O[P](O)(O)=O)(O)=O)(O[Li])OC[C@]1(O[C@@](C[C@@H]1O)([H])N2C3=NC(F)=NC(N)=C3N=C2)C#C.[Li].[Li].[Li]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (178.59 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7859 mL 8.9294 mL 17.8587 mL
5 mM 0.3572 mL 1.7859 mL 3.5717 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.7859 mL 8.9294 mL 17.8587 mL 44.6468 mL
5 mM 0.3572 mL 1.7859 mL 3.5717 mL 8.9294 mL
10 mM 0.1786 mL 0.8929 mL 1.7859 mL 4.4647 mL
15 mM 0.1191 mL 0.5953 mL 1.1906 mL 2.9765 mL
20 mM 0.0893 mL 0.4465 mL 0.8929 mL 2.2323 mL
25 mM 0.0714 mL 0.3572 mL 0.7143 mL 1.7859 mL
30 mM 0.0595 mL 0.2976 mL 0.5953 mL 1.4882 mL
40 mM 0.0446 mL 0.2232 mL 0.4465 mL 1.1162 mL
50 mM 0.0357 mL 0.1786 mL 0.3572 mL 0.8929 mL
60 mM 0.0298 mL 0.1488 mL 0.2976 mL 0.7441 mL
80 mM 0.0223 mL 0.1116 mL 0.2232 mL 0.5581 mL
100 mM 0.0179 mL 0.0893 mL 0.1786 mL 0.4465 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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EFdA-TP tetralithium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EFdA-TP tetralithiumHIVReverse TranscriptaseHuman immunodeficiency virusInhibitorinhibitorinhibit

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