2. Others Anti-infection
  3. Isotope-Labeled Compounds Fungal
  4. Efinaconazole-d4

Efinaconazole-d4  (Synonyms: KP-103-d4)

Cat. No.: HY-15660S Purity: 99.91%
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Efinaconazole-d4 is the deuterium labeled Efinaconazole. Efinaconazole (KP-103) is a triazole antifungal agent and againsts T. mentagrophytes SM-110 and C. albicans ATCC 10231 with MICs of 0.0039 μg/mL and 0.00098 μg/mL, respectively[1]. Efinaconazole has a potent in vitro activity against fungal pathogens including dermatophytes, Candida and Malassezia species[1].

For research use only. We do not sell to patients.

Efinaconazole-d<sub>4</sub> Chemical Structure

Efinaconazole-d4 Chemical Structure

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1 mg USD 300 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Efinaconazole-d4:

Efinaconazole-d4 Related Antibodies

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Description

Efinaconazole-d4 is the deuterium labeled Efinaconazole. Efinaconazole (KP-103) is a triazole antifungal agent and againsts T. mentagrophytes SM-110 and C. albicans ATCC 10231 with MICs of 0.0039 μg/mL and 0.00098 μg/mL, respectively[1]. Efinaconazole has a potent in vitro activity against fungal pathogens including dermatophytes, Candida and Malassezia species[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Efinaconazole-d4 Related Antibodies
Molecular Weight

352.41

Formula

C18H18D4F2N4O
Unlabeled CAS

164650-44-6
Appearance

Solid

Color

White to off-white

SMILES

C=C1CC([2H])(N(C([2H])(C1)[2H])[C@H](C)[C@](C2=CC=C(C=C2F)F)(O)CN3C=NC=N3)[2H]
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (283.76 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : ≥ 100 mg/mL (283.76 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8376 mL 14.1880 mL 28.3760 mL
5 mM 0.5675 mL 2.8376 mL 5.6752 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO 1 mM 2.8376 mL 14.1880 mL 28.3760 mL 70.9401 mL
5 mM 0.5675 mL 2.8376 mL 5.6752 mL 14.1880 mL
10 mM 0.2838 mL 1.4188 mL 2.8376 mL 7.0940 mL
15 mM 0.1892 mL 0.9459 mL 1.8917 mL 4.7293 mL
20 mM 0.1419 mL 0.7094 mL 1.4188 mL 3.5470 mL
25 mM 0.1135 mL 0.5675 mL 1.1350 mL 2.8376 mL
30 mM 0.0946 mL 0.4729 mL 0.9459 mL 2.3647 mL
40 mM 0.0709 mL 0.3547 mL 0.7094 mL 1.7735 mL
50 mM 0.0568 mL 0.2838 mL 0.5675 mL 1.4188 mL
60 mM 0.0473 mL 0.2365 mL 0.4729 mL 1.1823 mL
80 mM 0.0355 mL 0.1774 mL 0.3547 mL 0.8868 mL
100 mM 0.0284 mL 0.1419 mL 0.2838 mL 0.7094 mL
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Efinaconazole-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Efinaconazole-d4KP-103-d4Isotope-Labeled CompoundsFungalInhibitorinhibitorinhibit

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