2. Protein Tyrosine Kinase/RTK
  3. c-Fms
  4. Eflapegrastim

Eflapegrastim is a human IgG4 monoclonal antibody, is also a granulocyte colony-stimulating factor (G-CSF). Eflapegrastim targets to G-CSF receptor (c-Fms). Eflapegrastim stimulates proliferation and differentiation of neutrophil progenitor cells and maintains stable numbers of mature and functional neutrophils. Eflapegrastim also shortens the duration of neutropenia.

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CAS No. : 1384099-30-2

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Eflapegrastim Related Antibodies

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Description

Eflapegrastim is a human IgG4 monoclonal antibody, is also a granulocyte colony-stimulating factor (G-CSF). Eflapegrastim targets to G-CSF receptor (c-Fms). Eflapegrastim stimulates proliferation and differentiation of neutrophil progenitor cells and maintains stable numbers of mature and functional neutrophils. Eflapegrastim also shortens the duration of neutropenia[1].

Species

Human
In Vitro

Eflapegrastim has an IgG4 Fc fragment and short polyethylene glycol linker[1].
Eflapegrastim (5.5-88 mM; 4 min) binds to FcRn but not Fcγ receptors or C1q[1].
Eflapegrastim (0.000036-0.709 nmol/L; 54 h) induces bone marrow cell proliferation[1].
Eflapegrastim (10 μM; 1 h) binds FcRn and undergoes FcRn-mediated transcytosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Eflapegrastim Related Antibodies
In Vivo

Eflapegrastim (100 μg/kg; s.c.; single dose) decreases the duration of neutropenia (DN) and increases levels of G-CSF in serum and marrow in chemotherapy-induced neutropenic rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6NCrl mice (4-6 weeks old)[1]
Dosage: (1) 9, 26, 53, and 88 µg/kg; (2) 62 µg/kg
Administration: Subcutaneous injection; single dose
Result: Reduced chemotherapy-induced neutropenia.
Clinical Trial
CAS No.
SMILES

[Eflapegrastim]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • [CSF3 (colony stimulating factor 3, GCSF, granulocyte colony-stimulating factor, G-CSF)-PEG linker]1-IGHG4 Fc (Fragment constant)
Purity & Documentation
References
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Eflapegrastim Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Eflapegrastim1384099-30-2c-FmsCSF-1 receptorcolony stimulating factor 1 receptorCSF-1RCSF1RInhibitorinhibitorinhibit

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