2. Anti-infection
  3. Parasite
  4. Eflornithine hydrochloride

Eflornithine hydrochloride  (Synonyms: DFMO hydrochloride; MDL71782 hydrochloride; RMI71782 hydrochloride; α-difluoromethylornithine hydrochloride)

Cat. No.: HY-B0744A Purity: ≥98.0%
SDS COA Handling Instructions Technical Support

Eflornithine hydrochloride is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women.

For research use only. We do not sell to patients.

Eflornithine hydrochloride Chemical Structure

Eflornithine hydrochloride Chemical Structure

CAS No. : 68278-23-9

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Customer Review

Based on 10 publication(s) in Google Scholar

Other Forms of Eflornithine hydrochloride:

Eflornithine hydrochloride Related Antibodies

Top Publications Citing Use of Products

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • Biological Activity

  • Protocol

  • Purity & Documentation

  • References

  • Customer Review

Description

Eflornithine hydrochloride is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women.

IC50 & Target

Trypanosoma

 

Cellular Effect
Cell Line Type Value Description References
J774 IC50
> 1000 μM
Compound: S3
Cytotoxicity against J774.1 cell line after 48 hrs
Cytotoxicity against J774.1 cell line after 48 hrs
[PMID: 16516467]
In Vivo

Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is the drug used mainly as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases[1]. In subjects with excessive, unwanted facial hair, eflornithine 15% cream is superior to placebo in reducing hair growth. After 24 weeks' treatment, 58% of eflornithine and 34% of placebo subjects have at least some improvement in facial hirsutism[2]. The hair growth inhibitory activity of eflornithine is significantly enhanced when the eflornithine cream is applied onto a mouse skin area pretreated with microneedles[3]. Treatment of coarctation hypertensive rats with eflornithine results in a normalization of the contractile intensity to KCI and norepinephrine and relaxations to acetylcholine by 14 days of hypertension[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

218.63

Formula

C6H13ClF2N2O2
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

NC(CCCN)(C(F)F)C(O)=O.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (457.39 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.5739 mL 22.8697 mL 45.7394 mL
5 mM 0.9148 mL 4.5739 mL 9.1479 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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(per animal)

g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

SDS (393 KB)

COA (247 KB) HNMR (166 KB) MS (72 KB)

Handling Instructions (2659 KB)
References
Animal Administration
[3]

Mice: The skin area where the hair is removed is then treated with the eflornithine hydrochloride 13.9% cream (∼50 mg per mouse per treatment) using a spatula 2 times a day in an interval of at least 8 h for a maximum period of 36 days[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.5739 mL 22.8697 mL 45.7394 mL 114.3484 mL
5 mM 0.9148 mL 4.5739 mL 9.1479 mL 22.8697 mL
10 mM 0.4574 mL 2.2870 mL 4.5739 mL 11.4348 mL
15 mM 0.3049 mL 1.5246 mL 3.0493 mL 7.6232 mL
20 mM 0.2287 mL 1.1435 mL 2.2870 mL 5.7174 mL
25 mM 0.1830 mL 0.9148 mL 1.8296 mL 4.5739 mL
30 mM 0.1525 mL 0.7623 mL 1.5246 mL 3.8116 mL
40 mM 0.1143 mL 0.5717 mL 1.1435 mL 2.8587 mL
50 mM 0.0915 mL 0.4574 mL 0.9148 mL 2.2870 mL
60 mM 0.0762 mL 0.3812 mL 0.7623 mL 1.9058 mL
80 mM 0.0572 mL 0.2859 mL 0.5717 mL 1.4294 mL
100 mM 0.0457 mL 0.2287 mL 0.4574 mL 1.1435 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Eflornithine hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Eflornithine68278-23-9DFMOMDL71782RMI71782α-difluoromethylornithineMDL 71782MDL-71782RMI 71782RMI-71782ParasiteInhibitorinhibitorinhibit

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