2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Stem Cell/Wnt MAPK/ERK Pathway Apoptosis
  3. EGFR ERK STAT Apoptosis
  4. EGFR-IN-151

EGFR-IN-151 (Compound 10) inhibits EGFR and its downstream signaling pathways ERK/STAT3. EGFR-IN-151 inhibits the proliferation of a variety lung cancer cells (IC50s for NCI-H1781, HCC827, NCI-H3255 and NCI-H1975 is 11.7, 5.19, 7.32 and 1.53 μM, respectively), inhibits the colony formation and migration of H1975, arrests the cell cycle at G1 phase, and induces apoptosis in H1975.

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EGFR-IN-151 Chemical Structure

EGFR-IN-151 Chemical Structure

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EGFR-IN-151 Related Antibodies

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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ERK ERK1 ERK2 ERK5 ERK8

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STAT3 STAT5 STAT6 STAT1

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Description

EGFR-IN-151 (Compound 10) inhibits EGFR and its downstream signaling pathways ERK/STAT3. EGFR-IN-151 inhibits the proliferation of a variety lung cancer cells (IC50s for NCI-H1781, HCC827, NCI-H3255 and NCI-H1975 is 11.7, 5.19, 7.32 and 1.53 μM, respectively), inhibits the colony formation and migration of H1975, arrests the cell cycle at G1 phase, and induces apoptosis in H1975[1].

Molecular Weight

1134.11

Formula

C55H59N9O18
SMILES

O=C(O[C@H]1[C@@H](C2=CC(O)=C(O)C(O)=C2)OC3=C(C(OCC4=CN(CCOCCOCCOCCN5N=NC(C6=CC=CC(NC7=C8C=C(OCCOC)C(OCCOC)=CC8=NC=N7)=C6)=C5)N=N4)=CC(O)=C3)C1)C9=CC(O)=C(O)C(O)=C9
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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EGFR-IN-151 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-151EGFRERKSTATApoptosisEpidermal growth factor receptorErbB-1HER1Extracellular signal regulated kinasesNCI-H1781HCC827NCI-H3255NCI-H1975Inhibitorinhibitorinhibit

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