2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. EGFR-IN-28

EGFR-IN-28 is a potent EGFR inhibitor. EGFR-IN-28 has antitumor activity.

For research use only. We do not sell to patients.

EGFR-IN-28 Chemical Structure

EGFR-IN-28 Chemical Structure

CAS No. : 2754392-31-7

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EGFR-IN-28 Related Antibodies

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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Description

EGFR-IN-28 is a potent EGFR inhibitor. EGFR-IN-28 has antitumor activity[1].

IC50 & Target[1]

EGFR

 

In Vitro

EGFR-IN-28 inhibits Δ19Del, L858R, Δ19Del/T790M, L858R/T790M, Δ19Del/T790M/C797S, L858R/T790M/C797S (all IC50s≤50nM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

EGFR-IN-28 Related Antibodies
Molecular Weight

711.68

Formula

C31H39BrN10O3S
CAS No.
SMILES

CS(=O)(N(C1=C2N=CC=NC2=CC=C1NC3=NC(NC4=CC=C(N5CCC(N6CCN(C)CC6)CC5)C=C4OC)=NC=C3Br)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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EGFR-IN-28 Related Classifications

  • Molarity Calculator

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-282754392-31-7EGFREpidermal growth factor receptorErbB-1HER1Δ19DelL858RΔ19Del/T790ML858R/T790MΔ19Del/T790M/C797SL858R/T790M/C797SInhibitorinhibitorinhibit

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EGFR-IN-28
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HY-142681
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