2. Cell Cycle/DNA Damage
  3. Eukaryotic Initiation Factor (eIF)
  4. eIF4E-IN-2

eIF4E-IN-2 is a potent inhibitor of eukaryotic initiation factor 4e (eIF4e). eIF4E-IN-2 has the potential for researching eIF4e dependent diseases, including the research of cancer (extracted from patent WO2021003157A1, compound 1188). eIF4E-IN-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

eIF4E-IN-2 Chemical Structure

eIF4E-IN-2 Chemical Structure

CAS No. : 2575840-38-7

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1 mg USD 360 In-stock
5 mg USD 800 In-stock
10 mg USD 1280 In-stock
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Based on 1 publication(s) in Google Scholar

eIF4E-IN-2 Related Antibodies

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Description

eIF4E-IN-2 is a potent inhibitor of eukaryotic initiation factor 4e (eIF4e). eIF4E-IN-2 has the potential for researching eIF4e dependent diseases, including the research of cancer (extracted from patent WO2021003157A1, compound 1188)[1]. eIF4E-IN-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

eIF4

 

Molecular Weight

791.29

Formula

C37H33ClF2N8O4S2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

N#CC1=C(N(C2CCN(C3CC(F)(C3)F)CC2)C)N=CC(N=C(C)N4CC#CC5=CC=C(C=C5C6=CC=NC7=C6SC=C7C(NS(=O)(C)=O)=O)Cl)=C1C4=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (63.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2638 mL 6.3188 mL 12.6376 mL
5 mM 0.2528 mL 1.2638 mL 2.5275 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2638 mL 6.3188 mL 12.6376 mL 31.5940 mL
5 mM 0.2528 mL 1.2638 mL 2.5275 mL 6.3188 mL
10 mM 0.1264 mL 0.6319 mL 1.2638 mL 3.1594 mL
15 mM 0.0843 mL 0.4213 mL 0.8425 mL 2.1063 mL
20 mM 0.0632 mL 0.3159 mL 0.6319 mL 1.5797 mL
25 mM 0.0506 mL 0.2528 mL 0.5055 mL 1.2638 mL
30 mM 0.0421 mL 0.2106 mL 0.4213 mL 1.0531 mL
40 mM 0.0316 mL 0.1580 mL 0.3159 mL 0.7898 mL
50 mM 0.0253 mL 0.1264 mL 0.2528 mL 0.6319 mL
60 mM 0.0211 mL 0.1053 mL 0.2106 mL 0.5266 mL
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eIF4E-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

eIF4E-IN-22575840-38-7Eukaryotic Initiation Factor (eIF)eukaryotic initiation factor 4eeIF4ecancerInhibitorinhibitorinhibit

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