2. Immunology/Inflammation Anti-infection Apoptosis
  3. Thrombopoietin Receptor Bacterial Apoptosis
  4. Eltrombopag-13C4

Eltrombopag-13C4  (Synonyms: SB-497115-13C4)

Cat. No.: HY-15306S Purity: 97.89%
SDS COA Handling Instructions

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Eltrombopag-13C4 (SB-497115-13C4) is 13 sup>C-labeled Z-Eltrombopag. Z-Eltrombopag is an orally active thrombopoietin-receptor non-peptide agonist with platelet-stimulating activity for the study of chronic immune thrombocytopenia. Eltrombopag also has strong inhibitory effects on multidrug-resistant Staphylococcus aureus (Staphylococcus aureus) and can induce apoptosis (apoptosis) in liver cancer cells.

For research use only. We do not sell to patients.

Eltrombopag-<sup>13</sup>C<sub>4</sub> Chemical Structure

Eltrombopag-13C4 Chemical Structure

CAS No. : 1217230-31-3

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Based on 1 publication(s) in Google Scholar

Other Forms of Eltrombopag-13C4:

Eltrombopag-13C4 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Eltrombopag-13C4

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Description

Eltrombopag-13C4 (SB-497115-13C4) is 13 sup>C-labeled Z-Eltrombopag. Z-Eltrombopag is an orally active thrombopoietin-receptor non-peptide agonist with platelet-stimulating activity for the study of chronic immune thrombocytopenia. Eltrombopag also has strong inhibitory effects on multidrug-resistant Staphylococcus aureus (Staphylococcus aureus) and can induce apoptosis (apoptosis) in liver cancer cells[1][2][3][4][5].

IC50 & Target

Thrombopoietin Receptor, Staphylococcus aureus, Apoptosis[1][3][5]
Molecular Weight

446.44

Formula

C2113C4H22N4O4
CAS No.
Unlabeled CAS

496775-61-2
Appearance

Solid

Color

Light yellow to orange

SMILES

O=[13C](/[13C]1=N/NC(C=CC=C2C3=CC(C(O)=O)=CC=C3)=C2O)N(C(C=C4)=CC(C)=C4C)N=[13C]1[13CH3]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 20 mg/mL (44.80 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : ≥ 20 mg/mL (44.80 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMF : ≥ 1 mg/mL (2.24 mM)

DMF : ≥ 1 mg/mL (2.24 mM)

DMF:PBS (pH 7.2)(1:3) : ≥ 0.25 mg/mL (0.56 mM)

Ethanol : ≥ 0.1 mg/mL (0.22 mM)

Ethanol : ≥ 0.1 mg/mL (0.22 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2399 mL 11.1997 mL 22.3994 mL
5 mM 0.4480 mL 2.2399 mL 4.4799 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 97.89%

SDS (252 KB)

COA (247 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMF / DMF / DMSO / DMSO 1 mM 2.2399 mL 11.1997 mL 22.3994 mL 55.9986 mL
DMSO / DMSO 5 mM 0.4480 mL 2.2399 mL 4.4799 mL 11.1997 mL
10 mM 0.2240 mL 1.1200 mL 2.2399 mL 5.5999 mL
15 mM 0.1493 mL 0.7466 mL 1.4933 mL 3.7332 mL
20 mM 0.1120 mL 0.5600 mL 1.1200 mL 2.7999 mL
25 mM 0.0896 mL 0.4480 mL 0.8960 mL 2.2399 mL
30 mM 0.0747 mL 0.3733 mL 0.7466 mL 1.8666 mL
40 mM 0.0560 mL 0.2800 mL 0.5600 mL 1.4000 mL
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Eltrombopag-13C4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Eltrombopag-13C41217230-31-3SB-497115-13C4Thrombopoietin ReceptorBacterialApoptosisE-EltrombopagZ-EltrombopagEltrombopagthrombopoietinTPOthrombocytopeniaInhibitorinhibitorinhibit

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