2. Immunology/Inflammation Protein Tyrosine Kinase/RTK NF-κB Apoptosis
  3. IRAK FLT3 NF-κB MyD88 Apoptosis
  4. Emavusertib maleate

Emavusertib maleate  (Synonyms: CA-4948 maleate)

Cat. No.: HY-135317E
Handling Instructions Technical Support

Emavusertib maleate (CA-4948 maleate) is the maleate salt form of Emavusertib (HY-135317). Emavusertib maleate is an orally active inhibitor for IRAK4 (IC50=57 nM) and FLT3. Emavusertib maleate inhibits NF-κB and MyD88 signaling pathways, reduces the generation of pro-inflammatory cytokines like IL-6 and IL-10, thereby exhibiting anti-inflammatory and anti-proliferative activities against cancer cells, leading to cell apoptosis. Emavusertib maleate exhibits antitumor activity in mouse model.

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Emavusertib maleate Chemical Structure

Emavusertib maleate Chemical Structure

CAS No. : 2376399-39-0

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Emavusertib maleate Related Antibodies

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Description

Emavusertib maleate (CA-4948 maleate) is the maleate salt form of Emavusertib (HY-135317). Emavusertib maleate is an orally active inhibitor for IRAK4 (IC50=57 nM) and FLT3. Emavusertib maleate inhibits NF-κB and MyD88 signaling pathways, reduces the generation of pro-inflammatory cytokines like IL-6 and IL-10, thereby exhibiting anti-inflammatory and anti-proliferative activities against cancer cells, leading to cell apoptosis. Emavusertib maleate exhibits antitumor activity in mouse model[1][2][3].

Molecular Weight

607.57

Formula

C28H29N7O9
CAS No.
SMILES

OC(/C=C\C(O)=O)=O.O=C(C1=COC(C2=CC=NC(C)=C2)=N1)NC3=C(N4CC[C@H](C4)O)N=C5C(OC(N6CCOCC6)=N5)=C3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Emavusertib maleate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Emavusertib2376399-39-0CA-4948CA4948CA 4948IRAKFLT3NF-κBMyD88ApoptosisInterleukin-1 receptor associated kinaseIL-1R associated kinaseCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3Nuclear factor-κBNuclear factor-kappaBABC DLBCLMCLAMLselectiveorally activeInhibitorinhibitorinhibit

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