2. Immunology/Inflammation
  3. Complement System
  4. Empasiprubart

Empasiprubart  (Synonyms: ARGX-117)

Cat. No.: HY-P990025 Purity: 97.93%
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Empasiprubar (ARGX-117) is a humanized inhibitory monoclonal antibody targeting complement C2. Empasiprubar binds to the Sushi-2 domain of C2, preventing the formation of C3 pre convertase and inhibiting the activation of classical and lectin pathways upstream of C3 activation. Empasiprubar can prevent complement mediated autoimmune hemolytic anemia and antibody mediated organ transplant rejection. Empasiprubar can prevent neuroglial lymphoconjunctival injury in GM1 antibody mediated mouse models.

For research use only. We do not sell to patients.

CAS No. : 2579031-19-7

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Description

Empasiprubar (ARGX-117) is a humanized inhibitory monoclonal antibody targeting complement C2. Empasiprubar binds to the Sushi-2 domain of C2, preventing the formation of C3 pre convertase and inhibiting the activation of classical and lectin pathways upstream of C3 activation. Empasiprubar can prevent complement mediated autoimmune hemolytic anemia and antibody mediated organ transplant rejection. Empasiprubar can prevent neuroglial lymphoconjunctival injury in GM1 antibody mediated mouse models[1][2].
Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Humanized
In Vitro

Empasiprubar prevents complement mediated autoimmune hemolytic anemia and antibody mediated organ transplant rejection in an in vitro model[1].
Empasiprubar can inhibit C4 downstream complement activation induced by anti-GM1 antibody binding to motor neurons (MN) derived from induced pluripotent stem cells (iPSC) model[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Empasiprubart Related Antibodies
In Vivo

Empasiprubart (0.5-30 mg/kg; once daily; 60 days; i.v.) targets the classical pathway (CP) and lectin pathway (LP) inhibition in crab eating macaques, without affecting the alternative pathway (AP)[1].
Empasiprubart (200 mg/kg; once; i.v.) can prevent neuroglial lymphoconjunctival injury in GM1 antibody mediated mouse models[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cynomolgus monkeys[1].
Dosage: 0.5-30 mg/kg
Administration: Intravenous injection (i.v.); once daily; 60 days
Result: Reduced free C2 levels and classical pathway activity.
Animal Model: Schwann cell nodal membrane injury mice model[2].
Dosage: 200 mg/kg
Administration: Intravenous injection (i.v.); once
Result: Attenuated injury to paranodal proteins at the node of Ranvier and improves respiratory function in vivo Schwann cell nodal membrane injury models.
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Empasiprubart]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Empasiprubart2579031-19-7ARGX-117ARGX117ARGX 117Complement Systemcomplementclassic pathwaylectin pathwayhemolytic anemiaInhibitorinhibitorinhibit

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