2. PROTAC
  3. PROTAC Linkers
  4. endo-BCN-PEG4-NHS ester

endo-BCN-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. endo-BCN-PEG4-NHS ester is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

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endo-BCN-PEG4-NHS ester Chemical Structure

endo-BCN-PEG4-NHS ester Chemical Structure

CAS No. : 2252422-32-3

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5 mg USD 120 In-stock
10 mg USD 195 In-stock
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Based on 1 publication(s) in Google Scholar

endo-BCN-PEG4-NHS ester Related Antibodies

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Description

endo-BCN-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. endo-BCN-PEG4-NHS ester is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

endo-BCN-PEG4-NHS ester Related Antibodies
Molecular Weight

538.59

Formula

C26H38N2O10
CAS No.
Appearance

Liquid (Density: 1.28±0.1 g/cm3)

Color

Colorless to light yellow

SMILES

O=C(OCC1C2CCC#CCCC12)NCCOCCOCCOCCOCCC(ON3C(CCC3=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (464.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8567 mL 9.2835 mL 18.5670 mL
5 mM 0.3713 mL 1.8567 mL 3.7134 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.27%

COA (242 KB) HNMR (126 KB) LCMS (423 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8567 mL 9.2835 mL 18.5670 mL 46.4175 mL
5 mM 0.3713 mL 1.8567 mL 3.7134 mL 9.2835 mL
10 mM 0.1857 mL 0.9283 mL 1.8567 mL 4.6417 mL
15 mM 0.1238 mL 0.6189 mL 1.2378 mL 3.0945 mL
20 mM 0.0928 mL 0.4642 mL 0.9283 mL 2.3209 mL
25 mM 0.0743 mL 0.3713 mL 0.7427 mL 1.8567 mL
30 mM 0.0619 mL 0.3094 mL 0.6189 mL 1.5472 mL
40 mM 0.0464 mL 0.2321 mL 0.4642 mL 1.1604 mL
50 mM 0.0371 mL 0.1857 mL 0.3713 mL 0.9283 mL
60 mM 0.0309 mL 0.1547 mL 0.3094 mL 0.7736 mL
80 mM 0.0232 mL 0.1160 mL 0.2321 mL 0.5802 mL
100 mM 0.0186 mL 0.0928 mL 0.1857 mL 0.4642 mL
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endo-BCN-PEG4-NHS ester Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

endo-BCN-PEG4-NHS ester2252422-32-3PROTAC LinkersInhibitorinhibitorinhibit

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