2. Others Neuronal Signaling Protein Tyrosine Kinase/RTK Autophagy
  3. Autophagy Trk Receptor ROS Kinase Anaplastic lymphoma kinase (ALK) Isotope-Labeled Compounds
  4. Entrectinib-d8

Entrectinib-d8  (Synonyms: NMS-E628-d8; RXDX-101-d8)

Cat. No.: HY-12678S1 Purity: 99.82%
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Entrectinib-d8 (NMS-E628-d8; RXDX-101-d8) is a deuterated version of Entrectinib (HY-12678). Entrectinib (NMS-E628) is an orally available, blood-brain barrier permeable, central nervous system active TrkA/B/C, ROS1 and ALK inhibitor with IC50 values of 1, 3, 5, 12 and 12, respectively. 7 nM. Entrectinib induces apoptosis and cycle arrest in cancer cells, has anti-tumor activity, and also alleviates bleomycin-induced pulmonary fibrosis in mice.

For research use only. We do not sell to patients.

Entrectinib-d<sub>8</sub> Chemical Structure

Entrectinib-d8 Chemical Structure

CAS No. : 2251773-94-9

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1 mg USD 240 In-stock
5 mg USD 600 In-stock
10 mg USD 980 In-stock
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Based on 1 publication(s) in Google Scholar

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Entrectinib-d8 Related Antibodies

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Description

Entrectinib-d8 (NMS-E628-d8; RXDX-101-d8) is a deuterated version of Entrectinib (HY-12678). Entrectinib (NMS-E628) is an orally available, blood-brain barrier permeable, central nervous system active TrkA/B/C, ROS1 and ALK inhibitor with IC50 values of 1, 3, 5, 12 and 12, respectively. 7 nM. Entrectinib induces apoptosis and cycle arrest in cancer cells, has anti-tumor activity, and also alleviates bleomycin-induced pulmonary fibrosis in mice[1][2][3][4].

Molecular Weight

568.69

Formula

C31H26D8F2N6O2
CAS No.
Unlabeled CAS

1108743-60-7
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=NNC2=C1C=C(CC3=CC(F)=CC(F)=C3)C=C2)C4=C(NC5CCOCC5)C=C(N6C([2H])([2H])C([2H])([2H])N(C)C([2H])([2H])C6([2H])[2H])C=C4
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (175.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7584 mL 8.7921 mL 17.5843 mL
5 mM 0.3517 mL 1.7584 mL 3.5169 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7584 mL 8.7921 mL 17.5843 mL 43.9607 mL
5 mM 0.3517 mL 1.7584 mL 3.5169 mL 8.7921 mL
10 mM 0.1758 mL 0.8792 mL 1.7584 mL 4.3961 mL
15 mM 0.1172 mL 0.5861 mL 1.1723 mL 2.9307 mL
20 mM 0.0879 mL 0.4396 mL 0.8792 mL 2.1980 mL
25 mM 0.0703 mL 0.3517 mL 0.7034 mL 1.7584 mL
30 mM 0.0586 mL 0.2931 mL 0.5861 mL 1.4654 mL
40 mM 0.0440 mL 0.2198 mL 0.4396 mL 1.0990 mL
50 mM 0.0352 mL 0.1758 mL 0.3517 mL 0.8792 mL
60 mM 0.0293 mL 0.1465 mL 0.2931 mL 0.7327 mL
80 mM 0.0220 mL 0.1099 mL 0.2198 mL 0.5495 mL
100 mM 0.0176 mL 0.0879 mL 0.1758 mL 0.4396 mL
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Entrectinib-d8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Entrectinib-d82251773-94-9NMS-E628-d8 RXDX-101-d8AutophagyTrk ReceptorROS KinaseAnaplastic lymphoma kinase (ALK)Isotope-Labeled CompoundsTropomyosin related kinase receptor Anaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246KM12 cellscancerlung fibrosistumorfibroblasts cellsInhibitorinhibitorinhibit

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