2. MAPK/ERK Pathway
  3. p38 MAPK
  4. EO 1428

EO 1428 is a highly specific inhibitor of p38 of the aminobenzophenone class. EO 1428 (1 μM ) markedly attenuates LPS-induced tumor necrosis factor α-converting enzyme (TACE) activity up-regulation.

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EO 1428 Chemical Structure

EO 1428 Chemical Structure

CAS No. : 321351-00-2

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Based on 1 publication(s) in Google Scholar

EO 1428 Related Antibodies

Top Publications Citing Use of Products

View All p38 MAPK Isoform Specific Products:

View All Isoforms
p38 MAPK p38α p38β MAPK13 p38δ p38γ

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Description

EO 1428 is a highly specific inhibitor of p38 of the aminobenzophenone class. EO 1428 (1 μM ) markedly attenuates LPS-induced tumor necrosis factor α-converting enzyme (TACE) activity up-regulation[1].

Molecular Weight

415.71

Formula

C20H16BrClN2O
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C(C1=CC=C(NC2=CC=C(Br)C=C2N)C=C1Cl)C3=CC=CC=C3C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 41.57 mg/mL (100.00 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4055 mL 12.0276 mL 24.0552 mL
5 mM 0.4811 mL 2.4055 mL 4.8110 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.0%

SDS (251 KB)

COA (246 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4055 mL 12.0276 mL 24.0552 mL 60.1381 mL
5 mM 0.4811 mL 2.4055 mL 4.8110 mL 12.0276 mL
10 mM 0.2406 mL 1.2028 mL 2.4055 mL 6.0138 mL
15 mM 0.1604 mL 0.8018 mL 1.6037 mL 4.0092 mL
20 mM 0.1203 mL 0.6014 mL 1.2028 mL 3.0069 mL
25 mM 0.0962 mL 0.4811 mL 0.9622 mL 2.4055 mL
30 mM 0.0802 mL 0.4009 mL 0.8018 mL 2.0046 mL
40 mM 0.0601 mL 0.3007 mL 0.6014 mL 1.5035 mL
50 mM 0.0481 mL 0.2406 mL 0.4811 mL 1.2028 mL
60 mM 0.0401 mL 0.2005 mL 0.4009 mL 1.0023 mL
80 mM 0.0301 mL 0.1503 mL 0.3007 mL 0.7517 mL
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EO 1428 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EO 1428321351-00-2EO1428EO-1428p38 MAPKspecific p38 inhibitortumor necrosis factor α-converting enzymeTACEInhibitorinhibitorinhibit

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