Epiallopregnanolone (Synonyms: 5α,3β-THDOC)

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Epiallopregnanolone (5α,3β-THDOC), a 3β-hydroxy neurosteroid, an antagonist at GABAA receptors and a NMDA receptor enhancer.

For research use only. We do not sell to patients.

Epiallopregnanolone Chemical Structure

CAS No. : 567-01-1

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Description

Epiallopregnanolone (5α,3β-THDOC), a 3β-hydroxy neurosteroid, an antagonist at GABAA receptors and a NMDA receptor enhancer^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HEK-293T	IC₅₀	12.3 μM Compound: 34	Inhibition of G6PD in HEK293T cells assessed as accumulation of 6-phosphogluconate after 5 hrs by LC-MS/MS analysis using 6-aminonicotinamide Inhibition of G6PD in HEK293T cells assessed as accumulation of 6-phosphogluconate after 5 hrs by LC-MS/MS analysis using 6-aminonicotinamide	[PMID: 22506561]

In Vivo

Epiallopregnanolone (5α,3β-THDOC; 1-100 mg/kg; ip) inhibits seizures induced by Pilocarpine in mice (ED₅₀ of 45.9 mg/kg)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Swiss mice (25-30 g) injected with Pilocarpine^[2]
Dosage:	1-100 mg/kg
Administration:	ip; once
Result:	Inhibited seizures induced by Pilocarpine.

Molecular Weight

334.49

Formula

C₂₁H₃₄O₃

CAS No.

567-01-1

SMILES

C[C@]12[C@]([H])([C@@]3(CC[C@]4(C[C@H](CC[C@@]4([C@]3(CC2)[H])C)O)[H])[H])CC[C@@H]1C(CO)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Brett C Ginsburg, et al. Alphaxalone and epiallopregnanolone in rats trained to discriminate ethanol. Alcohol Clin Exp Res. 2005 Sep;29(9):1621-9. [Content Brief]

Epiallopregnanolone Related Classifications

Neurological Disease

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Epiallopregnanolone567-01-15α,3β-THDOCGABA ReceptoriGluRGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorIonotropic glutamate receptorsGABAA receptor3β-hydroxy neurosteroidNMDA receptorInhibitorinhibitorinhibit

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