2. PROTAC Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR PROTACs
  4. ERD-3111

ERD-3111 (Compound 44) is an orally active PROTAC ERα degrader (DC50: 0.5 nM). ERD-3111 inhibits tumor growth in the parental MCF-7 xenograft model with wild-type ER and two clinically relevant ESR1 mutated mice model. ERD-3111 can be used in the research of ER+ breast cancer.

For research use only. We do not sell to patients.

ERD-3111 Chemical Structure

ERD-3111 Chemical Structure

CAS No. : 2832865-25-3

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Based on 1 publication(s) in Google Scholar

ERD-3111 Related Antibodies

Top Publications Citing Use of Products

View All Estrogen Receptor/ERR Isoform Specific Products:

View All Isoforms
Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

View All PROTACs Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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  • Purity & Documentation

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Description

ERD-3111 (Compound 44) is an orally active PROTAC ERα degrader (DC50: 0.5 nM). ERD-3111 inhibits tumor growth in the parental MCF-7 xenograft model with wild-type ER and two clinically relevant ESR1 mutated mice model. ERD-3111 can be used in the research of ER+ breast cancer[1].

IC50 & Target

ERα[1]
Molecular Weight

854.89

Formula

C45H46F4N8O5
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

FC(CN1[C@@H](CC2=C([C@H]1C3=C(C=C(C=C3F)N4CCC5(CC4)CCN(C(CN6CC(C=C(C7=C8)C(N(C7=O)C9CCC(NC9=O)=O)=O)=C8C6)=O)CC5)F)C=CC%10=C2C=NN%10)C)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (116.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1697 mL 5.8487 mL 11.6974 mL
5 mM 0.2339 mL 1.1697 mL 2.3395 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1697 mL 5.8487 mL 11.6974 mL 29.2435 mL
5 mM 0.2339 mL 1.1697 mL 2.3395 mL 5.8487 mL
10 mM 0.1170 mL 0.5849 mL 1.1697 mL 2.9244 mL
15 mM 0.0780 mL 0.3899 mL 0.7798 mL 1.9496 mL
20 mM 0.0585 mL 0.2924 mL 0.5849 mL 1.4622 mL
25 mM 0.0468 mL 0.2339 mL 0.4679 mL 1.1697 mL
30 mM 0.0390 mL 0.1950 mL 0.3899 mL 0.9748 mL
40 mM 0.0292 mL 0.1462 mL 0.2924 mL 0.7311 mL
50 mM 0.0234 mL 0.1170 mL 0.2339 mL 0.5849 mL
60 mM 0.0195 mL 0.0975 mL 0.1950 mL 0.4874 mL
80 mM 0.0146 mL 0.0731 mL 0.1462 mL 0.3655 mL
100 mM 0.0117 mL 0.0585 mL 0.1170 mL 0.2924 mL
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ERD-3111 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ERD-31112832865-25-3ERD3111ERD 3111Estrogen Receptor/ERRPROTACsbreast cancerER+MCF-7tumorESR1 mutated modelwild-type ERInhibitorinhibitorinhibit

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