2. MAPK/ERK Pathway Stem Cell/Wnt
  3. ERK
  4. ERK1/2 inhibitor 9

ERK1/2 inhibitor 9 (Probe 1) is a covalent ERK1/2 inhibitor. ERK1/2 inhibitor 9 shows sub-micromolar activity in cells (A375 GI50=0.47 μM). ERK1/2 inhibitor 9 causes the downregulation of phospho-ERK1/2. ERK1/2 inhibitor 9 tagged trans-cyclo-octene (TCO) and Tz-Thalidomide (tetrazine tagged Thalidomide) can form the corresponding ERK-CLIPTAC to elicit degradation of ERK1/2.

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ERK1/2 inhibitor 9 Chemical Structure

ERK1/2 inhibitor 9 Chemical Structure

CAS No. : 2169302-75-2

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ERK1/2 inhibitor 9 Related Antibodies

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Description

ERK1/2 inhibitor 9 (Probe 1) is a covalent ERK1/2 inhibitor. ERK1/2 inhibitor 9 shows sub-micromolar activity in cells (A375 GI50=0.47 μM). ERK1/2 inhibitor 9 causes the downregulation of phospho-ERK1/2. ERK1/2 inhibitor 9 tagged trans-cyclo-octene (TCO) and Tz-Thalidomide (tetrazine tagged Thalidomide) can form the corresponding ERK-CLIPTAC to elicit degradation of ERK1/2[1].

IC50 & Target[1]

ERK1

 

ERK2

 

Molecular Weight

586.08

Formula

C31H32ClN7O3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(NCCC#CC1=NC=CC(NC2=NC=C(C(NC3=C(NC(C=C)=O)C=CC=C3)=N2)Cl)=C1)OC4CC/C=C\CCC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (85.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7063 mL 8.5313 mL 17.0625 mL
5 mM 0.3413 mL 1.7063 mL 3.4125 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7063 mL 8.5313 mL 17.0625 mL 42.6563 mL
5 mM 0.3413 mL 1.7063 mL 3.4125 mL 8.5313 mL
10 mM 0.1706 mL 0.8531 mL 1.7063 mL 4.2656 mL
15 mM 0.1138 mL 0.5688 mL 1.1375 mL 2.8438 mL
20 mM 0.0853 mL 0.4266 mL 0.8531 mL 2.1328 mL
25 mM 0.0683 mL 0.3413 mL 0.6825 mL 1.7063 mL
30 mM 0.0569 mL 0.2844 mL 0.5688 mL 1.4219 mL
40 mM 0.0427 mL 0.2133 mL 0.4266 mL 1.0664 mL
50 mM 0.0341 mL 0.1706 mL 0.3413 mL 0.8531 mL
60 mM 0.0284 mL 0.1422 mL 0.2844 mL 0.7109 mL
80 mM 0.0213 mL 0.1066 mL 0.2133 mL 0.5332 mL
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ERK1/2 inhibitor 9 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ERK1/2 inhibitor 92169302-75-2ERKExtracellular signal regulated kinasesA375phospho-ERK1/2trans-cyclo-octeneTCOTz-ThalidomidetetrazineERK-CLIPTACInhibitorinhibitorinhibit

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