2. Metabolic Enzyme/Protease
  3. Renin
  4. ES 6864

ES 6864 is an orally active, competitive inhibitor for human renin, with an IC50 of 6.9 nM and a Ki of 7.3 nM. ES 6864 exhibits high species-specific and enzyme-specific properties. ES 6864 exhibits metabolic stability in rat tissue homogenates. ES 6864 reduces blood pressure in rats and sodium-depleted awake marmosets.

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ES 6864 Chemical Structure

ES 6864 Chemical Structure

CAS No. : 116326-39-7

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Description

ES 6864 is an orally active, competitive inhibitor for human renin, with an IC50 of 6.9 nM and a Ki of 7.3 nM. ES 6864 exhibits high species-specific and enzyme-specific properties. ES 6864 exhibits metabolic stability in rat tissue homogenates. ES 6864 reduces blood pressure in rats and sodium-depleted awake marmosets[1].

IC50 & Target

IC50: 6.9 nM (human renin)
Molecular Weight

791.01

Formula

C42H58N6O7S
CAS No.
SMILES

O=C(N1CCOCC1)C[C@H](C(N[C@H](C(N[C@@H](CC2CCCCC2)[C@@H](O)CC(NCCN3CCOCC3)=O)=O)CC4=CSC=N4)=O)CC5=CC=CC6=C5C=CC=C6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ES 6864 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ES 6864116326-39-7ES6864ES-6864Reninorally activecompetitivespecies-specificmarmosetWistar ratInhibitorinhibitorinhibit

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