2. Metabolic Enzyme/Protease Immunology/Inflammation
  3. Endogenous Metabolite Toll-like Receptor (TLR)
  4. Ethyl glucuronide

Ethyl glucuronide is an endogenous metabolite. Ethyl glucuronide is the metabolite of ethanol. Ethyl glucuronide is a biomarker for ethanol exposure that accumulates in hair and reflects the alcohol intake over a time period. Ethyl glucuronide is the agonist for TLR4.

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Ethyl glucuronide Chemical Structure

Ethyl glucuronide Chemical Structure

CAS No. : 17685-04-0

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
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Based on 1 publication(s) in Google Scholar

Other Forms of Ethyl glucuronide:

Ethyl glucuronide Related Antibodies

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Description

Ethyl glucuronide is an endogenous metabolite. Ethyl glucuronide is the metabolite of ethanol. Ethyl glucuronide is a biomarker for ethanol exposure that accumulates in hair and reflects the alcohol intake over a time period. Ethyl glucuronide is the agonist for TLR4[1][2].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Ethyl glucuronide (0-100 μM, 24 h) blocks the formation of TLR4-MD2 complex, stimulates the expression of TLR4-depenent SEAP protein in HEK-TLR4 cell[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ethyl glucuronide Related Antibodies
In Vivo

Ethyl glucuronide (0.38 µg, intrathecal injection, single dose) reduces the tactile threshold, induces hyperalgesia in Sprague-Dawley rat models[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rat models[2]
Dosage: 0.38 µg
Administration: intrathecal injection, single dose
Result: Reduced the tactile threshold.
Clinical Trial
Molecular Weight

222.19

Formula

C8H14O7
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC([C@@H]1[C@H]([C@@H]([C@@H](O)[C@H](OCC)O1)O)O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (562.57 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.5006 mL 22.5030 mL 45.0059 mL
5 mM 0.9001 mL 4.5006 mL 9.0012 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.39%

SDS (393 KB)

COA (254 KB) HNMR (252 KB) RP-HPLC (237 KB) MS (69 KB) Elemental Analysis Report (112 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.5006 mL 22.5030 mL 45.0059 mL 112.5148 mL
5 mM 0.9001 mL 4.5006 mL 9.0012 mL 22.5030 mL
10 mM 0.4501 mL 2.2503 mL 4.5006 mL 11.2515 mL
15 mM 0.3000 mL 1.5002 mL 3.0004 mL 7.5010 mL
20 mM 0.2250 mL 1.1251 mL 2.2503 mL 5.6257 mL
25 mM 0.1800 mL 0.9001 mL 1.8002 mL 4.5006 mL
30 mM 0.1500 mL 0.7501 mL 1.5002 mL 3.7505 mL
40 mM 0.1125 mL 0.5626 mL 1.1251 mL 2.8129 mL
50 mM 0.0900 mL 0.4501 mL 0.9001 mL 2.2503 mL
60 mM 0.0750 mL 0.3750 mL 0.7501 mL 1.8752 mL
80 mM 0.0563 mL 0.2813 mL 0.5626 mL 1.4064 mL
100 mM 0.0450 mL 0.2250 mL 0.4501 mL 1.1251 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Ethyl glucuronide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ethyl glucuronide17685-04-0Endogenous MetaboliteToll-like Receptor (TLR)Sprague-Dawley ratHEK-TLR4hyperalgesiaInhibitorinhibitorinhibit

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