2. PROTAC
  3. PROTAC Linkers
  4. exo BCN-O-PNB

exo BCN-O-PNB is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. exo BCN-O-PNB is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

For research use only. We do not sell to patients.

exo BCN-O-PNB Chemical Structure

exo BCN-O-PNB Chemical Structure

CAS No. : 1380006-72-3

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100 mg USD 143 In-stock
250 mg USD 238 In-stock
1 g USD 593 In-stock
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Based on 1 publication(s) in Google Scholar

exo BCN-O-PNB Related Antibodies

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Description

exo BCN-O-PNB is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. exo BCN-O-PNB is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC50 & Target

Alkyl/ether

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

exo BCN-O-PNB Related Antibodies
Molecular Weight

315.32

Formula

C17H17NO5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(OC[C@H]1[C@]2([H])CCC#CCC[C@]12[H])OC3=CC=C([N+]([O-])=O)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥98.0%

COA (248 KB) HNMR (130 KB)

Handling Instructions (2659 KB)
References
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exo BCN-O-PNB Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

exo BCN-O-PNB1380006-72-3PROTAC LinkersInhibitorinhibitorinhibit

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