F092

Cat. No.: HY-139171 Purity: 99.79%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

F092 is an inhibitor of hematopoietic prostaglandin D synthase (H-PGDS) with a K_D value of 0.14 nM. F092 can be used in the study of allergic and inflammatory responses.

For research use only. We do not sell to patients.

F092 Chemical Structure

CAS No. : 2250261-59-5

Size	Price	Stock	Quantity
1 mg	USD 70	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 240	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 400	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Description

F092 is an inhibitor of hematopoietic prostaglandin D synthase (H-PGDS) with a K_D value of 0.14 nM. F092 can be used in the study of allergic and inflammatory responses^[1].

IC₅₀ & Target

KD: 0.14 nM (H-PGDS)^[1].

Molecular Weight

359.38

Formula

C₂₀H₁₇N₅O₂

CAS No.

2250261-59-5

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CN=C(C2=NC=CC=C2)N=C1)NC3=CC=C(N4C(CCC4)=O)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (347.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7826 mL	13.9128 mL	27.8257 mL
5 mM	0.5565 mL	2.7826 mL	5.5651 mL
10 mM	0.2783 mL	1.3913 mL	2.7826 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.79%

Select Batch:

Data Sheet (270 KB) SDS (252 KB)

COA (248 KB) HNMR (249 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. Takaya D, et al. Characterization of crystal water molecules in a high-affinity inhibitor and hematopoietic prostaglandin D synthase complex by interaction energy studies[J]. Bioorganic & Medicinal Chemistry, 2018, 26(16): 4726-4734. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7826 mL	13.9128 mL	27.8257 mL	69.5642 mL
	5 mM	0.5565 mL	2.7826 mL	5.5651 mL	13.9128 mL
	10 mM	0.2783 mL	1.3913 mL	2.7826 mL	6.9564 mL
	15 mM	0.1855 mL	0.9275 mL	1.8550 mL	4.6376 mL
	20 mM	0.1391 mL	0.6956 mL	1.3913 mL	3.4782 mL
	25 mM	0.1113 mL	0.5565 mL	1.1130 mL	2.7826 mL
	30 mM	0.0928 mL	0.4638 mL	0.9275 mL	2.3188 mL
	40 mM	0.0696 mL	0.3478 mL	0.6956 mL	1.7391 mL
	50 mM	0.0557 mL	0.2783 mL	0.5565 mL	1.3913 mL
	60 mM	0.0464 mL	0.2319 mL	0.4638 mL	1.1594 mL
	80 mM	0.0348 mL	0.1739 mL	0.3478 mL	0.8696 mL
	100 mM	0.0278 mL	0.1391 mL	0.2783 mL	0.6956 mL

F092 Related Classifications

Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

F0922250261-59-5F 092F-092PGE synthaseProstaglandin E synthaseallergiesinflammatory reactionsInhibitorinhibitorinhibit

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