2. Cell Cycle/DNA Damage TGF-beta/Smad Stem Cell/Wnt Cytoskeleton Neuronal Signaling Membrane Transporter/Ion Channel Autophagy Epigenetics
  3. ROCK Calcium Channel Autophagy PKA PKC
  4. Fasudil mesylate

Fasudil mesylate  (Synonyms: HA-1077 mesylate; AT-877 mesylate)

Cat. No.: HY-10341D
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Fasudil (HA-1077; AT877) mesylate is a nonspecific and orally active RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil mesylate is also a potent Ca2+ channel antagonist and vasodilator.

For research use only. We do not sell to patients.

Fasudil mesylate Chemical Structure

Fasudil mesylate Chemical Structure

CAS No. : 1001206-62-7

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Fasudil mesylate Related Antibodies

Top Publications Citing Use of Products

    Fasudil mesylate purchased from MedChemExpress. Usage Cited in: Biomed Rep. 2015 May;3(3):361-364.  [Abstract]

    RhoA and ROCK2 upregulation in the rat hippocampus is involved in memory dysfunction induced by postnatal exposure of Sevoflurane. The expression of RhoA, ROCK2 and cleaved caspase-3 (Cl-Csp3) in the hippocampus of the S3 group significantly increased, compared to that of the C group (P<0.05). There is no difference of the level of RhoA, ROCK2 and Cl-Csp3 between the C and S1 groups (P>0.05). ROCK2 inhibitor Fasudil hydrochloride in the F group clearly decreases the expression of ROCK2 and Cl-Cs

    View All ROCK Isoform Specific Products:

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    ROCK ROCK1 ROCK2

    View All Calcium Channel Isoform Specific Products:

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    N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

    View All PKA Isoform Specific Products:

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    PKA PKAR

    View All PKC Isoform Specific Products:

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    PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKC-ι ℩ PKCι

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    Description

    Fasudil (HA-1077; AT877) mesylate is a nonspecific and orally active RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil mesylate is also a potent Ca2+ channel antagonist and vasodilator[1][2][3][4][5][6].

    IC50 & Target

    Ki: 0.33 μM (ROCK1)[1]
    IC50: 0.158 μM (ROCK2), 4.58 μM (PKA), 12.30 μM (PKC), 1.650 μM (PKG)[1]
    Molecular Weight

    387.47

    Formula

    C15H21N3O5S2
    CAS No.
    SMILES

    CS(O)(=O)=O.O=S(C1=CC=CC2=C1C=CN=C2)(N3CCNCCC3)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Fasudil mesylate Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Fasudil1001206-62-7HA-1077AT-877HA1077HA 1077AT877AT 877ROCKCalcium ChannelAutophagyPKAPKCRho-associated protein kinaseRho-associated kinaseRho-kinaseROKCa2+ channelsCa channelsProtein kinase AProtein kinase Ccollagena-SMATIMP-1ERK1/2JNKp38rat HSCshuman HSCTWNT-4 cellsvasodilatorlysophoaphatidic acidLPAInhibitorinhibitorinhibit

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