Fenofibric acid-d₆

Name: Fenofibric acid-d 6
Brand: MedChemExpress
SKU: HY-B0760S
Rating: 5.0 (1 reviews)

Cat. No.: HY-B0760S Purity: 99.58%: FAQs
Data Sheet SDS COA Handling Instructions

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Fenofibric acid-d₆ (FNF acid-d6) is the deuterium labeled Fenofibric acid. Fenofibric acid, an active metabolite of fenofibrate, is a PPAR activitor, with EC50s of 22.4 µM, 1.47 µM, and 1.06 µM for PPARα, PPARγ and PPARδ, respectively; Fenofibric acid also inhibits COX-2 enzyme activity, with an IC50 of 48 nM.

For research use only. We do not sell to patients.

Fenofibric acid-d<sub>6</sub> Chemical Structure

Fenofibric acid-d₆ Chemical Structure

CAS No. : 1092484-69-9

Size	Price	Stock	Quantity
1 mg	USD 120	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 340	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Fenofibric acid-d₆:

Fenofibric acid In-stock

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•Related Small Molecules:

•Related Proteins:

View All PPAR Isoform Specific Products:

View All Isoforms

PPARα PPARβ/δ PPARγ PPAR PPARδ

View All COX Isoform Specific Products:

View All Isoforms

COX COX-1 COX-2 COX-3

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

324.79

Formula

C₁₇H₉D₆ClO₄

CAS No.

1092484-69-9

Unlabeled CAS

42017-89-0

Appearance

Solid

Color

White to off-white

SMILES

C(=O)(C1=CC=C(OC(C(O)=O)(C([2H])([2H])[2H])C([2H])([2H])[2H])C=C1)C2=CC=C(Cl)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (307.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0789 mL	15.3946 mL	30.7891 mL
5 mM	0.6158 mL	3.0789 mL	6.1578 mL
10 mM	0.3079 mL	1.5395 mL	3.0789 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.58%

Select Batch:

Data Sheet (273 KB) SDS (251 KB)

COA (248 KB) HNMR (476 KB) RP-HPLC (884 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Dietz M, et al. Comparative molecular profiling of the PPARα/γ activator aleglitazar: PPAR selectivity, activity and interaction with cofactors. ChemMedChem. 2012 Jun;7(6):1101-11. [Content Brief]

[3]. Prasad GS, et al. Anti-inflammatory activity of anti-hyperlipidemic drug, fenofibrate, and its phase-I metabolite fenofibric acid: in silico, in vitro, and in vivo studies. Inflammopharmacology. 2017 Dec 13. [Content Brief]

[4]. Neumeier M, et al. Aldehyde oxidase 1 is highly abundant in hepatic steatosis and is downregulated by adiponectin and fenofibric acid in hepatocytes in vitro. Biochem Biophys Res Commun. 2006 Nov 24;350(3):731-5. Epub 2006 Sep 27. [Content Brief]

[5]. Miranda S, et al. Beneficial effects of fenofibrate in retinal pigment epithelium by the modulation of stress and survival signaling under diabetic conditions. J Cell Physiol. 2012 Jun;227(6):2352-62. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.0789 mL	15.3946 mL	30.7891 mL	76.9728 mL
	5 mM	0.6158 mL	3.0789 mL	6.1578 mL	15.3946 mL
	10 mM	0.3079 mL	1.5395 mL	3.0789 mL	7.6973 mL
	15 mM	0.2053 mL	1.0263 mL	2.0526 mL	5.1315 mL
	20 mM	0.1539 mL	0.7697 mL	1.5395 mL	3.8486 mL
	25 mM	0.1232 mL	0.6158 mL	1.2316 mL	3.0789 mL
	30 mM	0.1026 mL	0.5132 mL	1.0263 mL	2.5658 mL
	40 mM	0.0770 mL	0.3849 mL	0.7697 mL	1.9243 mL
	50 mM	0.0616 mL	0.3079 mL	0.6158 mL	1.5395 mL
	60 mM	0.0513 mL	0.2566 mL	0.5132 mL	1.2829 mL
	80 mM	0.0385 mL	0.1924 mL	0.3849 mL	0.9622 mL
	100 mM	0.0308 mL	0.1539 mL	0.3079 mL	0.7697 mL