2. GPCR/G Protein Membrane Transporter/Ion Channel Neuronal Signaling
  3. 5-HT Receptor Monoamine Transporter
  4. FFN246

FFN246 is a fluorescent, dual substrate of serotonin transporter (SERT) probe and vesicular monoamine transporter 2 (VMAT2) with excitation and emission spectra 392/427 nm. FFN246 can be used for labeling serotonergic neurons in mouse brain tissue through SERT-dependent accumulation.

For research use only. We do not sell to patients.

FFN246 Chemical Structure

FFN246 Chemical Structure

CAS No. : 2210244-83-8

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5 mg USD 113 In-stock
10 mg USD 203 In-stock
25 mg USD 447 In-stock
50 mg USD 805 In-stock
100 mg USD 1450 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

FFN246 is a fluorescent, dual substrate of serotonin transporter (SERT) probe and vesicular monoamine transporter 2 (VMAT2) with excitation and emission spectra 392/427 nm. FFN246 can be used for labeling serotonergic neurons in mouse brain tissue through SERT-dependent accumulation[1].

In Vivo

FFN246 (2.5-20 μM, 30 mins) can be used for direct examination of serotonin transporter (SERT) activity and SERT inhibitors in 96-well cell culture assays, as well as specific labeling of serotonergic neurons of the dorsal raphe nucleus in the living tissue of acute mouse brain slices[1].
FFN246 (20 μM, 30 mins) effectively traces serotonin uptake and packaging in the soma of serotonergic neurons[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

256.27

Formula

C15H13FN2O
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C2=CC(CCN)=CC=C2NC3=C1C(F)=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 16.67 mg/mL (65.05 mM; ultrasonic and warming and adjust pH to 1 with 1 M HCL and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9021 mL 19.5107 mL 39.0213 mL
5 mM 0.7804 mL 3.9021 mL 7.8043 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.79%

COA (245 KB) HNMR (228 KB) LCMS (89 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.9021 mL 19.5107 mL 39.0213 mL 97.5534 mL
5 mM 0.7804 mL 3.9021 mL 7.8043 mL 19.5107 mL
10 mM 0.3902 mL 1.9511 mL 3.9021 mL 9.7553 mL
15 mM 0.2601 mL 1.3007 mL 2.6014 mL 6.5036 mL
20 mM 0.1951 mL 0.9755 mL 1.9511 mL 4.8777 mL
25 mM 0.1561 mL 0.7804 mL 1.5609 mL 3.9021 mL
30 mM 0.1301 mL 0.6504 mL 1.3007 mL 3.2518 mL
40 mM 0.0976 mL 0.4878 mL 0.9755 mL 2.4388 mL
50 mM 0.0780 mL 0.3902 mL 0.7804 mL 1.9511 mL
60 mM 0.0650 mL 0.3252 mL 0.6504 mL 1.6259 mL
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FFN246 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FFN2462210244-83-8FFN 246FFN-2465-HT ReceptorMonoamine TransporterSerotonin Receptor5-hydroxytryptamine ReceptorImaging probeInhibitorinhibitorinhibit

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