FGA145

Cat. No.: HY-161244: FAQs
Data Sheet Handling Instructions

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FGA145 is a dual, selective inhibitor for M^pro and human Cathepsin L, with K_is of 3.71 μM, 9.82 μM and 53 nM, for Mal-M^pro, pET21-M^pro and Cathepsin L, respectively. FGA145 reveals a multitarget effects in the antiviral activity.

For research use only. We do not sell to patients.

FGA145 Chemical Structure

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•Related Small Molecules:

•Related Proteins:

View All Cathepsin Isoform Specific Products:

View All Isoforms

Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin K Cathepsin L Cathepsin S

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

cathepsin L

53 nM (Ki)

Cathepsin B

206 nM (Ki)

In Vitro

FGA145 reveals weak antiviral activity against SARS-CoV-2 with EC₅₀ of 11.7 μM with low cytotoxicity in Huh-7-ACE2 cells (CC₅₀ over 100 μM)^[1].
FGA145 exhibits inhibitory properties towards cysteine proteases RhD, CRZ, Cat L and Cat B, with K_is of 1.63, 12.6, 53 and 206 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:	Huh-7-ACE2
Concentration:	0-100 μM
Incubation Time:	24 h
Result:	Exhibited a CC₅₀ of over 100 μM.

Molecular Weight

442.51

Formula

C₂₃H₃₀N₄O₅

SMILES

O=C(N[C@@H](C[C@@H]1CCNC1=O)/C=C/[N+]([O-])=O)[C@H](CC(C)C)NC(/C=C/C2=CC=CC=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Medrano FJ, et al., Peptidyl nitroalkene inhibitors of main protease rationalized by computational and crystallographic investigations as antivirals against SARS-CoV-2. Commun Chem. 2024 Jan 18;7(1):15. [Content Brief]

FGA145 Related Classifications

Infection

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FGA145FGA 145FGA-145SARS-CoVCathepsinVirus ProteaseSARS coronavirusSARS-CoV-2Huh-7-ACE2pMal-M^pro vectorpET21-M^pro vectorInhibitorinhibitorinhibit

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