FGA146

Cat. No.: HY-161245: FAQs
Data Sheet Handling Instructions Technical Support

FGA146 is a dual, selective inhibitor for M^pro and human Cathepsin L, with K_is of 2.19 μM, 0.96 μM and 0.87 μM, for Mal-M^pro, pET21-M^pro and Cathepsin L, respectively. FGA146 reveals an antiviral activity against SARS-CoV-2.

For research use only. We do not sell to patients.

FGA146 Chemical Structure

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View All Isoforms

Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin K Cathepsin L Cathepsin S

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

cathepsin L

0.87 μM (Ki)

pET21-M^pro

0.96 μM (Ki)

Mal-M^pro

2.19 μM (Ki)

In Vitro

FGA146 reveals antiviral activity against SARS-CoV-2 with EC₅₀ of 0.9 μM with low cytotoxicity^[1].
FGA146 (25-100 μM) binds covalently to M^pro and decreases its thermal stability^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:	Huh-7-ACE2
Concentration:	0-100 μM
Incubation Time:	24 h
Result:	Exhibited a CC₅₀ of over 100 μM.

Molecular Weight

485.53

Formula

C₂₄H₃₁N₅O₆

SMILES

O=C(N[C@@H](C[C@@H]1CCNC1=O)/C=C/[N+]([O-])=O)[C@H](CC(C)C)NC(C2=CC(C(OC)=CC=C3)=C3N2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Medrano FJ, et al., Peptidyl nitroalkene inhibitors of main protease rationalized by computational and crystallographic investigations as antivirals against SARS-CoV-2. Commun Chem. 2024 Jan 18;7(1):15. [Content Brief]

FGA146 Related Classifications

Infection

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FGA146FGA 146FGA-146Virus ProteaseCathepsinSARS-CoV-2Huh-7-ACE2pMal-M^pro vectorpET21-M^pro vectorInhibitorinhibitorinhibit

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