2. Anti-infection Metabolic Enzyme/Protease
  3. Virus Protease Cathepsin
  4. FGA146

FGA146 is a dual, selective inhibitor for Mpro and human Cathepsin L, with Kis of 2.19 μM, 0.96 μM and 0.87 μM, for Mal-Mpro, pET21-Mpro and Cathepsin L, respectively. FGA146 reveals an antiviral activity against SARS-CoV-2.

For research use only. We do not sell to patients.

FGA146 Chemical Structure

FGA146 Chemical Structure

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FGA146 Related Antibodies

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Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin K Cathepsin L Cathepsin S

  • Biological Activity

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Description

FGA146 is a dual, selective inhibitor for Mpro and human Cathepsin L, with Kis of 2.19 μM, 0.96 μM and 0.87 μM, for Mal-Mpro, pET21-Mpro and Cathepsin L, respectively. FGA146 reveals an antiviral activity against SARS-CoV-2[1].

IC50 & Target[1]

cathepsin L

0.87 μM (Ki)

pET21-Mpro

0.96 μM (Ki)

Mal-Mpro

2.19 μM (Ki)

In Vitro

FGA146 reveals antiviral activity against SARS-CoV-2 with EC50 of 0.9 μM with low cytotoxicity[1].
FGA146 (25-100 μM) binds covalently to Mpro and decreases its thermal stability[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FGA146 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: Huh-7-ACE2
Concentration: 0-100 μM
Incubation Time: 24 h
Result: Exhibited a CC50 of over 100 μM.
Molecular Weight

485.53

Formula

C24H31N5O6
SMILES

O=C(N[C@@H](C[C@@H]1CCNC1=O)/C=C/[N+]([O-])=O)[C@H](CC(C)C)NC(C2=CC(C(OC)=CC=C3)=C3N2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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FGA146 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FGA146FGA 146FGA-146Virus ProteaseCathepsinSARS-CoV-2Huh-7-ACE2pMal-Mpro vectorpET21-Mpro vectorInhibitorinhibitorinhibit

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