2. Anti-infection
  3. Influenza Virus
  4. Firivumab

Firivumab  (Synonyms: CT-P22; CT120)

Cat. No.: HY-P99620 Purity: 95.00%
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Firivumab (CT-P22; CT120) is a human IgG1 monoclonal influenza A virus hemagglutinin (Anti-IAV HA) antibody. Firivumab is capable of neutralizing H1N1, H5N1, H6N1, H6N2, H8N4, H8N8, H9N2 and H12N7. Firivumab shows protection against H1N1 virus in mice.

For research use only. We do not sell to patients.

CAS No. : 1443004-15-6

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Based on 1 publication(s) in Google Scholar

Firivumab Related Antibodies

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Description

Firivumab (CT-P22; CT120) is a human IgG1 monoclonal influenza A virus hemagglutinin (Anti-IAV HA) antibody. Firivumab is capable of neutralizing H1N1, H5N1, H6N1, H6N2, H8N4, H8N8, H9N2 and H12N7. Firivumab shows protection against H1N1 virus in mice[1][2][3].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Human
IC50 & Target

IC50: 0.1-1.3 μg/mL (H1N1), 0.78 μg/mL (H2N2), 0.48-0.65 μg/mL (H5N1), 4.69 μg/mL (H6N1), 4.69 μg/mL (H6N2), 2.34 μg/mL (H8N4), 1.3 μg/mL (H8N8), 2.08 μg/mL (H9N2) and 20.83 μg/mL (H12N7)[1]
In Vivo

Firivumab (CT-P22; CT120; 7.5-30 mg/kg; IP; Twenty-four hours post-infection) shows 100% protection against H1N1 virus in >15 mg/kg-treated group and 70% in 7.5 mg/kg-treated group[1].
CT-P27 (adding 7.5 mg/kg Firivumab and 7.5 mg/kg CT149) shows full protection in A/California/04/09 (H1N1)-treated mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six- to nine-week-old female BALB/c mice with A/California/04/09 (H1N1) and A/Philippines/2/1982 (H3N2)[1]
Dosage: 7.5, 15, 30 mg/kg
Administration: IP; Twenty-four hours post-infection
Result: Showed 100% protection against H1N1 virus in >15 mg/kg-treated group and 70% in 7.5 mg/kg-treated group.
Could not protect mice from H3N2 infection.
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Firivumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Purity & Documentation
References
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Firivumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Firivumab1443004-15-6CT-P22 CT120CT120CT 120CT-120Influenza VirusHumanIgG1influenza A virushemagglutininAnti-IAV HAH1N1H2N2H5N1H6N1H6N2H8N4H8N8H9N2H12N7A/California/04/09A/Philippines/2/1982CT-P27CT149Inhibitorinhibitorinhibit

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