2. Cell Cycle/DNA Damage
  3. Telomerase
  4. FKB04

FKB04 is a telomeric repeat binding factor 2 (TRF2) inhibitor that exerts its antitumor activity by disrupting the telomere maintenance mechanism in liver cancer cells, leading to T-loop defects, telomere shortening, and cellular senescence. Additionally, FKB04 can inhibit tumor growth in a human liver cancer xenograft mouse model (with Huh-7 cells implanted in BALB/c mice). FKB04 can be used in liver cancer research.

For research use only. We do not sell to patients.

FKB04 Chemical Structure

FKB04 Chemical Structure

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
Solid
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10 mg In-stock
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Based on 1 publication(s) in Google Scholar

FKB04 Related Antibodies

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Description

FKB04 is a telomeric repeat binding factor 2 (TRF2) inhibitor that exerts its antitumor activity by disrupting the telomere maintenance mechanism in liver cancer cells, leading to T-loop defects, telomere shortening, and cellular senescence. Additionally, FKB04 can inhibit tumor growth in a human liver cancer xenograft mouse model (with Huh-7 cells implanted in BALB/c mice). FKB04 can be used in liver cancer research[1].

IC50 & Target

Telomere repeat binding factor 2 (TRF2)[1]
Molecular Weight

363.20

Formula

C17H15BrO4
Appearance

Solid

Color

Light yellow to yellow

SMILES

BrC1=CC(/C=C/C(C2=C(C=C(C=C2O)OC)OC)=O)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (275.33 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7533 mL 13.7665 mL 27.5330 mL
5 mM 0.5507 mL 2.7533 mL 5.5066 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7533 mL 13.7665 mL 27.5330 mL 68.8326 mL
5 mM 0.5507 mL 2.7533 mL 5.5066 mL 13.7665 mL
10 mM 0.2753 mL 1.3767 mL 2.7533 mL 6.8833 mL
15 mM 0.1836 mL 0.9178 mL 1.8355 mL 4.5888 mL
20 mM 0.1377 mL 0.6883 mL 1.3767 mL 3.4416 mL
25 mM 0.1101 mL 0.5507 mL 1.1013 mL 2.7533 mL
30 mM 0.0918 mL 0.4589 mL 0.9178 mL 2.2944 mL
40 mM 0.0688 mL 0.3442 mL 0.6883 mL 1.7208 mL
50 mM 0.0551 mL 0.2753 mL 0.5507 mL 1.3767 mL
60 mM 0.0459 mL 0.2294 mL 0.4589 mL 1.1472 mL
80 mM 0.0344 mL 0.1721 mL 0.3442 mL 0.8604 mL
100 mM 0.0275 mL 0.1377 mL 0.2753 mL 0.6883 mL
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FKB04 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FKB04FKB 04FKB-04TelomeraseInhibitorinhibitorinhibit

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