Flecainide-d₄ acetate (Synonyms: R-818-d₄)

Name: Flecainide-d 4 acetate
Brand: MedChemExpress
SKU: HY-17429S
Rating: 4.5 (1 reviews)

Cat. No.: HY-17429S Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Flecainide-d₄ (acetate) is the deuterium labeled Flecainide acetate. Flecainide acetate (R-818) is a class 1C antiarrhythmic agent especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential[1][2].

For research use only. We do not sell to patients.

Flecainide-d<sub>4</sub> acetate Chemical Structure

Flecainide-d₄ acetate Chemical Structure

CAS No. : 1276197-21-7

Size	Price	Stock	Quantity
1 mg	USD 165	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Flecainide-d₄ acetate:

Flecainide acetate In-stock

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Sodium Channel Isoform Specific Products:

View All Isoforms

Na_v1.1 Na_v1.2 Na_v1.3 Na_v1.4 Na_v1.5 Na_v1.6 Na_v1.7 Na_v1.8

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

478.42

Formula

C₁₉H₂₀D₄F₆N₂O₅

CAS No.

1276197-21-7

Unlabeled CAS

54143-56-5

Appearance

Solid

Color

White to off-white

SMILES

CC(O)=O.O=C(C1=C(C=CC(OC([2H])([2H])C(F)(F)F)=C1)OC([2H])([2H])C(F)(F)F)NCC2CCCCN2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (104.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 20 mg/mL (41.80 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0902 mL	10.4511 mL	20.9021 mL
5 mM	0.4180 mL	2.0902 mL	4.1804 mL
10 mM	0.2090 mL	1.0451 mL	2.0902 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (249 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Yamashita T, Nakajima T, Hamada E, Flecainide inhibits the transient outward current in atrial myocytes isolated from the rabbit heart. J Pharmacol Exp Ther. 1995 Jul;274(1):315-21. [Content Brief]

[3]. Desaphy JF, De Luca A, Didonna MP, Different flecainide sensitivity of hNav1.4 channels and myotonic mutants explained by state-dependent block. J Physiol. 2004 Jan 15;554(Pt 2):321-34. [Content Brief]

[4]. Kohli V. Oral flecainide is effective in management of refractory tachycardia in infants. Indian Heart J. 2013 Mar-Apr;65(2):168-71. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / H₂O / DMSO / DMSO	1 mM	2.0902 mL	10.4511 mL	20.9021 mL	52.2553 mL
	5 mM	0.4180 mL	2.0902 mL	4.1804 mL	10.4511 mL
	10 mM	0.2090 mL	1.0451 mL	2.0902 mL	5.2255 mL
	15 mM	0.1393 mL	0.6967 mL	1.3935 mL	3.4837 mL
	20 mM	0.1045 mL	0.5226 mL	1.0451 mL	2.6128 mL
	25 mM	0.0836 mL	0.4180 mL	0.8361 mL	2.0902 mL
	30 mM	0.0697 mL	0.3484 mL	0.6967 mL	1.7418 mL
	40 mM	0.0523 mL	0.2613 mL	0.5226 mL	1.3064 mL
DMSO / DMSO	50 mM	0.0418 mL	0.2090 mL	0.4180 mL	1.0451 mL
	60 mM	0.0348 mL	0.1742 mL	0.3484 mL	0.8709 mL
	80 mM	0.0261 mL	0.1306 mL	0.2613 mL	0.6532 mL
	100 mM	0.0209 mL	0.1045 mL	0.2090 mL	0.5226 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Flecainide-d₄ acetate Related Classifications

Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Flecainide-d₄1276197-21-7R-818-d₄Sodium ChannelNa channelsNa+ channelsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *

Organization Name *

Country or Region *

Remarks

Name
Email *

	Sorry, but the email address you supplied was invalid.

Flecainide-d4 acetate (Synonyms: R-818-d4)

Customer Review

Other Forms of Flecainide-d4 acetate:

Flecainide-d4 acetate Related Antibodies

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Sodium Channel Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Flecainide-d4 acetate Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Flecainide-d4 acetate Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report

Flecainide-d₄ acetate (Synonyms: R-818-d₄)

Other Forms of Flecainide-d₄ acetate:

Flecainide-d₄ acetate Related Antibodies

Flecainide-d₄ acetate Related Antibodies

Flecainide-d₄ acetate Related Classifications