2. Others GPCR/G Protein Neuronal Signaling
  3. Isotope-Labeled Compounds 5-HT Receptor
  4. Flibanserin-d4-1

Flibanserin-d4-1  (Synonyms: BIMT-17-d4-1; BIMT-17BS-d4-1)

Cat. No.: HY-A0095S1 Purity: 99.28%
SDS COA Handling Instructions

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Flibanserin-d4-1 is deuterium labeled Flibanserin. Flibanserin (BIMT-17) is a full agonist of the serotonin 5-HT1A receptor (Ki=1 nM) and an antagonist of 5-HT2A (49 nM). Flibanserin binds to dopamine D4 receptors (4-24 nM), and has negligible affinity for a variety of other neurotransmitter receptors and ion channels. Flibanserin is efficacious in treating hypoactive sexual desire disorder (HSDD)[1][2].

For research use only. We do not sell to patients.

Flibanserin-d<sub>4</sub>-1 Chemical Structure

Flibanserin-d4-1 Chemical Structure

CAS No. : 2122830-91-3

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1 mg USD 320 In-stock
5 mg USD 850 In-stock
10 mg USD 1450 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Flibanserin-d4-1:

Flibanserin-d4-1 Related Antibodies

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5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

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Description

Flibanserin-d4-1 is deuterium labeled Flibanserin. Flibanserin (BIMT-17) is a full agonist of the serotonin 5-HT1A receptor (Ki=1 nM) and an antagonist of 5-HT2A (49 nM). Flibanserin binds to dopamine D4 receptors (4-24 nM), and has negligible affinity for a variety of other neurotransmitter receptors and ion channels. Flibanserin is efficacious in treating hypoactive sexual desire disorder (HSDD)[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Flibanserin-d4-1 Related Antibodies
Molecular Weight

394.43

Formula

C20H17D4F3N4O
CAS No.
Unlabeled CAS

167933-07-5
Appearance

Solid

Color

White to off-white

SMILES

FC(F)(F)C1=CC=CC(N(CC2)CCN2C([2H])([2H])C([2H])([2H])N3C4=CC=CC=C4NC3=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (126.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 50 mg/mL (126.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5353 mL 12.6765 mL 25.3530 mL
5 mM 0.5071 mL 2.5353 mL 5.0706 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO 1 mM 2.5353 mL 12.6765 mL 25.3530 mL 63.3826 mL
5 mM 0.5071 mL 2.5353 mL 5.0706 mL 12.6765 mL
10 mM 0.2535 mL 1.2677 mL 2.5353 mL 6.3383 mL
15 mM 0.1690 mL 0.8451 mL 1.6902 mL 4.2255 mL
20 mM 0.1268 mL 0.6338 mL 1.2677 mL 3.1691 mL
25 mM 0.1014 mL 0.5071 mL 1.0141 mL 2.5353 mL
30 mM 0.0845 mL 0.4226 mL 0.8451 mL 2.1128 mL
40 mM 0.0634 mL 0.3169 mL 0.6338 mL 1.5846 mL
50 mM 0.0507 mL 0.2535 mL 0.5071 mL 1.2677 mL
60 mM 0.0423 mL 0.2113 mL 0.4226 mL 1.0564 mL
80 mM 0.0317 mL 0.1585 mL 0.3169 mL 0.7923 mL
100 mM 0.0254 mL 0.1268 mL 0.2535 mL 0.6338 mL
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Flibanserin-d4-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Flibanserin-d4-12122830-91-3BIMT-17-d4-1BIMT-17BS-d4-1Isotope-Labeled Compounds5-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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