Floctafenine

Name: Floctafenine
Brand: MedChemExpress
SKU: HY-A0259
Rating: 4.5 (1 reviews)

Cat. No.: HY-A0259: FAQs
Data Sheet Handling Instructions

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Floctafenine, a nonsteroidal anti-inflammatory agent (NSAID), acts as an effective analgesic agent. Floctafenine is an inhibitor of COX-1 and COX-2 activities in vitro,showing a slightly higher potency towards COX-I. Floctafenine is used for the research of short term pain research.

For research use only. We do not sell to patients.

Floctafenine Chemical Structure

CAS No. : 23779-99-9

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5 mg USD 150 Get quote 4 - 6 weeks 4 - 6 weeks 3 - 5 weeks

Estimated Time of Arrival: December 31

10 mg USD 250 Get quote 4 - 6 weeks 4 - 6 weeks 3 - 5 weeks

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25 mg USD 500 Get quote 4 - 6 weeks 4 - 6 weeks 3 - 5 weeks

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Estimated Time of Arrival: December 31

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Based on 1 publication(s) in Google Scholar

Floctafenine Related Antibodies

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COX COX-1 COX-2 COX-3

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Description

Floctafenine, a nonsteroidal anti-inflammatory agent (NSAID), acts as an effective analgesic agent^[1]^[2]. Floctafenine is an inhibitor of COX-1 and COX-2 activities in vitro,showing a slightly higher potency towards COX-I. Floctafenine is used for the research of short term pain research^[3].

IC₅₀ & Target^[1]

COX-1

COX-2

In Vitro

Floctafenine (0.1-100 μM; in the presence of LPS; 24 hours) is slightly more potent 1.5-fold to inhibit in vitro platelet COX-I than monocyte COX-2. The IC₅₀ values for platelet COX-I and monocyte COX-2 inhibition are 2.33 μM (95%CI) and 3.47 μM (95%CI), respectively in heparinized whole blood samples^[3].
Floctafenine (0.1-100 μM; in the presence of A23187; 1 hour) does not significantly affect A23187-caused LTB4 generation even up to 100 μM^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Floctafenine Related Antibodies

In Vivo

Floctafenine (intraperitoneal injection; 50 mg/kg; single dose; 30 minutes prior to p-benzoquinone) has an inhibitory effects on p-benoquinone-induced writhing in rats, inhibition of writhing is 65.98%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight
406.36

Formula
C₂₀H₁₇F₃N₂O₄

CAS No.
23779-99-9

SMILES
O=C(OCC(O)CO)C1=CC=CC=C1NC2=CC=NC3=C(C(F)(F)F)C=CC=C23

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro:

DMSO : 41 mg/mL (100.90 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass 1 mg 5 mg 10 mg

1 mM 2.4609 mL 12.3044 mL 24.6087 mL

5 mM 0.4922 mL 2.4609 mL 4.9217 mL

10 mM 0.2461 mL 1.2304 mL 2.4609 mL

View the Complete Stock Solution Preparation Table

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Data Sheet (276 KB) Handling Instructions (2659 KB)

References

[1]. P Giuseppe, et al. Floctafenine: a valid alternative in patients with adverse reactions to nonsteroidal anti-inflammatory drugs. Ann Allergy Asthma Immunol. 1997 Jan;78(1):74-8. [Content Brief]

[2]. Gehan Hegazy Hegazy, et al. Synthesis of some floctafenine derivatives of expected anti-inflammatory/analgesic activity. Arch Pharm (Weinheim). 2005 Aug;338(8):378-84. [Content Brief]

[3]. R Maenthaisong, et al. Clinical pharmacology of cyclooxygenase inhibition and pharmacodynamic interaction with aspirin by floctafenine in Thai healthy subjects.Int J Immunopathol Pharmacol. Apr-Jun 2013;26(2):403-17. [Content Brief]

[1]. P Giuseppe, et al. Floctafenine: a valid alternative in patients with adverse reactions to nonsteroidal anti-inflammatory drugs. Ann Allergy Asthma Immunol. 1997 Jan;78(1):74-8.

[2]. Gehan Hegazy Hegazy, et al. Synthesis of some floctafenine derivatives of expected anti-inflammatory/analgesic activity. Arch Pharm (Weinheim). 2005 Aug;338(8):378-84.

[3]. R Maenthaisong, et al. Clinical pharmacology of cyclooxygenase inhibition and pharmacodynamic interaction with aspirin by floctafenine in Thai healthy subjects.Int J Immunopathol Pharmacol. Apr-Jun 2013;26(2):403-17.

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg

DMSO 1 mM 2.4609 mL 12.3044 mL 24.6087 mL 61.5218 mL

5 mM 0.4922 mL 2.4609 mL 4.9217 mL 12.3044 mL

10 mM 0.2461 mL 1.2304 mL 2.4609 mL 6.1522 mL

15 mM 0.1641 mL 0.8203 mL 1.6406 mL 4.1015 mL

20 mM 0.1230 mL 0.6152 mL 1.2304 mL 3.0761 mL

25 mM 0.0984 mL 0.4922 mL 0.9843 mL 2.4609 mL

30 mM 0.0820 mL 0.4101 mL 0.8203 mL 2.0507 mL

40 mM 0.0615 mL 0.3076 mL 0.6152 mL 1.5380 mL

50 mM 0.0492 mL 0.2461 mL 0.4922 mL 1.2304 mL

60 mM 0.0410 mL 0.2051 mL 0.4101 mL 1.0254 mL

80 mM 0.0308 mL 0.1538 mL 0.3076 mL 0.7690 mL

100 mM 0.0246 mL 0.1230 mL 0.2461 mL 0.6152 mL

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Floctafenine Related Classifications

Inflammation/Immunology

Immunology/Inflammation

COX

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Floctafenine23779-99-9COXCyclooxygenasenonsteroidal anti-inflammatory agentNSAIDanti-inflammatoryacute inflammationpaw edemapostoperative painosteoarthriticulcerogenicInhibitorinhibitorinhibit

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Size	Price	Stock	Quantity
5 mg	USD 150	Get quote 4 - 6 weeks 4 - 6 weeks 3 - 5 weeks	Estimated Time of Arrival: December 31
10 mg	USD 250	Get quote 4 - 6 weeks 4 - 6 weeks 3 - 5 weeks	Estimated Time of Arrival: December 31
25 mg	USD 500	Get quote 4 - 6 weeks 4 - 6 weeks 3 - 5 weeks	Estimated Time of Arrival: December 31
50 mg	USD 800	Get quote 4 - 6 weeks 4 - 6 weeks 3 - 5 weeks	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

DMSO	1 mM	2.4609 mL	12.3044 mL	24.6087 mL	61.5218 mL
	5 mM	0.4922 mL	2.4609 mL	4.9217 mL	12.3044 mL
	10 mM	0.2461 mL	1.2304 mL	2.4609 mL	6.1522 mL
	15 mM	0.1641 mL	0.8203 mL	1.6406 mL	4.1015 mL
	20 mM	0.1230 mL	0.6152 mL	1.2304 mL	3.0761 mL
	25 mM	0.0984 mL	0.4922 mL	0.9843 mL	2.4609 mL
	30 mM	0.0820 mL	0.4101 mL	0.8203 mL	2.0507 mL
	40 mM	0.0615 mL	0.3076 mL	0.6152 mL	1.5380 mL
	50 mM	0.0492 mL	0.2461 mL	0.4922 mL	1.2304 mL
	60 mM	0.0410 mL	0.2051 mL	0.4101 mL	1.0254 mL
	80 mM	0.0308 mL	0.1538 mL	0.3076 mL	0.7690 mL
	100 mM	0.0246 mL	0.1230 mL	0.2461 mL	0.6152 mL

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Floctafenine

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Floctafenine Related Antibodies

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•Related Proteins:

View All COX Isoform Specific Products:

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Floctafenine Related Antibodies

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Complete Stock Solution Preparation Table

Floctafenine Related Classifications

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