2. Immunology/Inflammation
  3. COX
  4. Floctafenine

Floctafenine, a nonsteroidal anti-inflammatory agent (NSAID), acts as an effective analgesic agent. Floctafenine is an inhibitor of COX-1 and COX-2 activities in vitro,showing a slightly higher potency towards COX-I. Floctafenine is used for the research of short term pain research.

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Floctafenine Chemical Structure

Floctafenine Chemical Structure

CAS No. : 23779-99-9

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Floctafenine Related Antibodies

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Description

Floctafenine, a nonsteroidal anti-inflammatory agent (NSAID), acts as an effective analgesic agent[1][2]. Floctafenine is an inhibitor of COX-1 and COX-2 activities in vitro,showing a slightly higher potency towards COX-I. Floctafenine is used for the research of short term pain research[3].

IC50 & Target[1]

COX-1

 

COX-2

 

In Vitro

Floctafenine (0.1-100 μM; in the presence of LPS; 24 hours) is slightly more potent 1.5-fold to inhibit in vitro platelet COX-I than monocyte COX-2. The IC50 values for platelet COX-I and monocyte COX-2 inhibition are 2.33 μM (95%CI) and 3.47 μM (95%CI), respectively in heparinized whole blood samples[3].
Floctafenine (0.1-100 μM; in the presence of A23187; 1 hour) does not significantly affect A23187-caused LTB4 generation even up to 100 μM[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Floctafenine Related Antibodies
In Vivo

Floctafenine (intraperitoneal injection; 50 mg/kg; single dose; 30 minutes prior to p-benzoquinone) has an inhibitory effects on p-benoquinone-induced writhing in rats, inhibition of writhing is 65.98%[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

406.36

Formula

C20H17F3N2O4
CAS No.
SMILES

O=C(OCC(O)CO)C1=CC=CC=C1NC2=CC=NC3=C(C(F)(F)F)C=CC=C23
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 41 mg/mL (100.90 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4609 mL 12.3044 mL 24.6087 mL
5 mM 0.4922 mL 2.4609 mL 4.9217 mL
View the Complete Stock Solution Preparation Table

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Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4609 mL 12.3044 mL 24.6087 mL 61.5218 mL
5 mM 0.4922 mL 2.4609 mL 4.9217 mL 12.3044 mL
10 mM 0.2461 mL 1.2304 mL 2.4609 mL 6.1522 mL
15 mM 0.1641 mL 0.8203 mL 1.6406 mL 4.1015 mL
20 mM 0.1230 mL 0.6152 mL 1.2304 mL 3.0761 mL
25 mM 0.0984 mL 0.4922 mL 0.9843 mL 2.4609 mL
30 mM 0.0820 mL 0.4101 mL 0.8203 mL 2.0507 mL
40 mM 0.0615 mL 0.3076 mL 0.6152 mL 1.5380 mL
50 mM 0.0492 mL 0.2461 mL 0.4922 mL 1.2304 mL
60 mM 0.0410 mL 0.2051 mL 0.4101 mL 1.0254 mL
80 mM 0.0308 mL 0.1538 mL 0.3076 mL 0.7690 mL
100 mM 0.0246 mL 0.1230 mL 0.2461 mL 0.6152 mL
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Floctafenine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Floctafenine23779-99-9COXCyclooxygenasenonsteroidal anti-inflammatory agentNSAIDanti-inflammatoryacute inflammationpaw edemapostoperative painosteoarthriticulcerogenicInhibitorinhibitorinhibit

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