Fluphenazine-d₈ dihydrochloride

Name: Fluphenazine-d 8 dihydrochloride
Brand: MedChemExpress
SKU: HY-A0081S
Rating: 4.5 (1 reviews)

Cat. No.: HY-A0081S Purity: 99.81%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Fluphenazine-d₈ (dihydrochloride) is the deuterium labeled Fluphenazine dihydrochloride. Fluphenazine dihydrochloride is a phenothiazine-class D1DR and D2DR inhibitor; used to deliver Fluphenazine to biological systems in studies probing the effects and metabolic fates of this commonly used dopamine antagonist.

For research use only. We do not sell to patients.

Fluphenazine-d<sub>8</sub> dihydrochloride Chemical Structure

Fluphenazine-d₈ dihydrochloride Chemical Structure

Size	Price	Stock	Quantity
1 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 1450	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 2400	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Fluphenazine-d₈ dihydrochloride:

Fluphenazine dihydrochloride In-stock
Fluphenazine-d₈ Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

518.49

Formula

C₂₂H₂₀D₈Cl₂F₃N₃OS

Unlabeled CAS

146-56-5

Appearance

Solid

Color

White to off-white

SMILES

FC(C1=CC=C2SC3=C(C=CC=C3)N(C2=C1)CCCN4C([2H])(C([2H])(N(CCO)C([2H])(C4([2H])[2H])[2H])[2H])[2H])(F)F.[2HCl]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (192.87 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9287 mL	9.6434 mL	19.2868 mL
5 mM	0.3857 mL	1.9287 mL	3.8574 mL
10 mM	0.1929 mL	0.9643 mL	1.9287 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.81%

Select Batch:

Data Sheet (272 KB) SDS (644 KB)

COA (249 KB) HNMR (327 KB) RP-HPLC (427 KB) MS (134 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Trzeciak HI, et al. Behavioral effects of withdrawal of fluphenazine after long-term treatment. Arzneimittelforschung. 1976;26(9):1697-700. [Content Brief]

[3]. Whelpton R, Curry SH. Effect of 20, 6Methods for study of fluphenazine kinetics in man. J Pharm Pharmacol. 1976 Dec;28(12):869-73. [Content Brief]

[4]. Javaid JI, et al. Fluphenazine determination in human plasma by a sensitive gas chromatographic method using nitrogen detector. J Chromatogr Sci. 1981 Sep;19(9):439-43. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / H₂O	1 mM	1.9287 mL	9.6434 mL	19.2868 mL	48.2169 mL
	5 mM	0.3857 mL	1.9287 mL	3.8574 mL	9.6434 mL
	10 mM	0.1929 mL	0.9643 mL	1.9287 mL	4.8217 mL
	15 mM	0.1286 mL	0.6429 mL	1.2858 mL	3.2145 mL
	20 mM	0.0964 mL	0.4822 mL	0.9643 mL	2.4108 mL
	25 mM	0.0771 mL	0.3857 mL	0.7715 mL	1.9287 mL
	30 mM	0.0643 mL	0.3214 mL	0.6429 mL	1.6072 mL
	40 mM	0.0482 mL	0.2411 mL	0.4822 mL	1.2054 mL
	50 mM	0.0386 mL	0.1929 mL	0.3857 mL	0.9643 mL
	60 mM	0.0321 mL	0.1607 mL	0.3214 mL	0.8036 mL
	80 mM	0.0241 mL	0.1205 mL	0.2411 mL	0.6027 mL
	100 mM	0.0193 mL	0.0964 mL	0.1929 mL	0.4822 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.