2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. Fluphenazine decanoate dihydrochloride

Fluphenazine decanoate dihydrochloride is a dopamine D2 receptor inhibitor, is a long-acting phenothiazine neuroleptic. Fluphenazine can be used for schizophrenia research.

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Fluphenazine decanoate dihydrochloride Chemical Structure

Fluphenazine decanoate dihydrochloride Chemical Structure

CAS No. : 2376-65-0

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Fluphenazine decanoate dihydrochloride Related Antibodies

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Description

Fluphenazine decanoate dihydrochloride is a dopamine D2 receptor inhibitor, is a long-acting phenothiazine neuroleptic. Fluphenazine can be used for schizophrenia research[1][2][3].

IC50 & Target

D2 Receptor

 

In Vitro

Fluphenazine decanoate dihydrochloride shows activity against T. gondii in human fibroblast cell cultures with an IC50 value of 1.7 mM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fluphenazine decanoate dihydrochloride Related Antibodies
In Vivo

Fluphenazine decanoate dihydrochloride (0.22 mg/kg and followed by 0.33 mg/kg; i.m.; 8 times every 3 weeks), as an antipsychotic, increases sensitivity to dopamine on monkey model following extended treatment[2].
Fluphenazine decanoate dihydrochloride (25 mg/kg; i.m.; 6 times every 3 weeks; 24 weeks) induces mouth movements in the rat, serves as a pharmacological model of human tardive dyskinesia[3].
Fluphenazine decanoate dihydrochloride (1, 2, 3 mg/kg/d; s.c.; 60 d) shows antifertility effects and induces hyperprolactinemia concomitant with gonadotropin suppression in adult male rat[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cebus apella monkey[2]
Dosage: 0.22 mg/kg and followed by 0.33 mg/kg
Administration: Intramuscular injection; 8 times per 3 weeks; 0.22 mg/kg for 63 weeks and 0.33 mg/kg for 6 weeks
Result: Decreased the aggressiveness composite behavioral variables (CBV).
Resulted stereotypic behavior induced by agonist and decreased prolactin response to AMPH.
Animal Model: Male Sprague-Dawley rats (250 g)[3]
Dosage: 25 mg/kg
Administration: Intramuscular injection into the hind limb; 24 weeks
Result: Resulted in spontaneous vacuous chewing mouth movements and jaw tremor.
Animal Model: Adult male rats[4]
Dosage: 1, 2, 3 mg/kg/d
Administration: Subcutaneous injection between 10:00-12:00 h; 60 days
Result: Increased serum prolactin level and suppressed serum LH and FSH levels at day 60.
Increased hypothalamic tyrosine hydroxylase levels, enhanced chromatin decondensation, and resulted DNA denaturation.
Clinical Trial
Molecular Weight

664.69

Formula

C32H46Cl2F3N3O2S
CAS No.
SMILES

CCCCCCCCCC(OCCN1CCN(CCCN2C3=C(C=CC=C3)SC4=CC=C(C(F)(F)F)C=C24)CC1)=O.[H]Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Fluphenazine decanoate dihydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fluphenazine decanoate2376-65-0Dopamine Receptorlong-actingphenothiazineneurolepticschizophreniadopamine-D2reproductiveT. gondiihypothalamic tyrosine hydroxylase levelshuman tardive dyskinesiagonadotropin suppressionantifertilityhyperprolactinemiamouth movementsvacuous chewing mouth movementjaw tremorserum prolactinInhibitorinhibitorinhibit

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