Fmoc-Ala-Glu-Asn-Lys-NH2

Name: Fmoc-Ala-Glu-Asn-Lys-NH2
Brand: MedChemExpress
SKU: HY-114174
Rating: 4.5 (1 reviews)

Cat. No.: HY-114174 Purity: 99.62%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage. AEP, a pH-controlled cysteine proteinase, is activated during ageing and mediates APP proteolytic processing.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Fmoc-Ala-Glu-Asn-Lys-NH2 Chemical Structure

CAS No. : 220701-06-4

Size	Price	Stock	Quantity
5 mg	USD 135	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 235	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

Fmoc-Ala-Glu-Asn-Lys-NH2 antagonizes APP processing by AEP, whereas other small molecular inhibitors and inactive peptide AEQK were without effect^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

681.74

Formula

C₃₃H₄₃N₇O₉

CAS No.

220701-06-4

Appearance

Solid

Color

White to off-white

Sequence Shortening

{Fmoc}-AENK-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light, under nitrogen

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (146.68 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : ≥ 10 mg/mL (14.67 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4668 mL	7.3342 mL	14.6683 mL
5 mM	0.2934 mL	1.4668 mL	2.9337 mL
10 mM	0.1467 mL	0.7334 mL	1.4668 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.62%

Select Batch:

Data Sheet (274 KB) SDS (252 KB)

COA (250 KB) RP-HPLC (109 KB) MS (217 KB)

Handling Instructions (2659 KB)

References

[1]. Zhang Z, et al. Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease. Nat Commun. 2015;6:8762. Published 2015 Nov 9. [Content Brief]

[2]. Chen G, et al. Netrin-1 receptor UNC5C cleavage by active δ-secretase enhances neurodegeneration, promoting Alzheimer's disease pathologies. Sci Adv. 2021 Apr 16;7(16):eabe4499. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	1.4668 mL	7.3342 mL	14.6683 mL	36.6709 mL
	5 mM	0.2934 mL	1.4668 mL	2.9337 mL	7.3342 mL
	10 mM	0.1467 mL	0.7334 mL	1.4668 mL	3.6671 mL
DMSO	15 mM	0.0978 mL	0.4889 mL	0.9779 mL	2.4447 mL
	20 mM	0.0733 mL	0.3667 mL	0.7334 mL	1.8335 mL
	25 mM	0.0587 mL	0.2934 mL	0.5867 mL	1.4668 mL
	30 mM	0.0489 mL	0.2445 mL	0.4889 mL	1.2224 mL
	40 mM	0.0367 mL	0.1834 mL	0.3667 mL	0.9168 mL
	50 mM	0.0293 mL	0.1467 mL	0.2934 mL	0.7334 mL
	60 mM	0.0244 mL	0.1222 mL	0.2445 mL	0.6112 mL
	80 mM	0.0183 mL	0.0917 mL	0.1834 mL	0.4584 mL
	100 mM	0.0147 mL	0.0733 mL	0.1467 mL	0.3667 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.