Fmoc-Cit-OH (Synonyms: Fmoc-L-Citrulline)

Cat. No.: HY-W008064 Purity: 99.32%: FAQs
Data Sheet SDS COA Handling Instructions

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Fmoc-Cit-OH (Fmoc-L-Citrulline) is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize a degradable ADC linker composed of a valine-citrulline (Val-Cit) motif.

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Custom Peptide Synthesis

Fmoc-Cit-OH Chemical Structure

CAS No. : 133174-15-9

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Description

Fmoc-Cit-OH (Fmoc-L-Citrulline) is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize a degradable ADC linker composed of a valine-citrulline (Val-Cit) motif^[1].

Molecular Weight

397.42

Formula

C₂₁H₂₃N₃O₅

CAS No.

133174-15-9

Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (251.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5162 mL	12.5811 mL	25.1623 mL
5 mM	0.5032 mL	2.5162 mL	5.0325 mL
10 mM	0.2516 mL	1.2581 mL	2.5162 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.32%

Select Batch:

Data Sheet (268 KB) SDS (394 KB)

COA (248 KB) HNMR (136 KB) RP-HPLC (236 KB) LCMS (97 KB)

Handling Instructions (2659 KB)

References

[1]. Pryyma, et al. "Rapid, high-yielding solid-phase synthesis of cathepsin-B cleavable linkers for targeted cancer therapeutics." Bioconjugate Chemistry 31.12 (2020): 2685-2690. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5162 mL	12.5811 mL	25.1623 mL	62.9057 mL
	5 mM	0.5032 mL	2.5162 mL	5.0325 mL	12.5811 mL
	10 mM	0.2516 mL	1.2581 mL	2.5162 mL	6.2906 mL
	15 mM	0.1677 mL	0.8387 mL	1.6775 mL	4.1937 mL
	20 mM	0.1258 mL	0.6291 mL	1.2581 mL	3.1453 mL
	25 mM	0.1006 mL	0.5032 mL	1.0065 mL	2.5162 mL
	30 mM	0.0839 mL	0.4194 mL	0.8387 mL	2.0969 mL
	40 mM	0.0629 mL	0.3145 mL	0.6291 mL	1.5726 mL
	50 mM	0.0503 mL	0.2516 mL	0.5032 mL	1.2581 mL
	60 mM	0.0419 mL	0.2097 mL	0.4194 mL	1.0484 mL
	80 mM	0.0315 mL	0.1573 mL	0.3145 mL	0.7863 mL
	100 mM	0.0252 mL	0.1258 mL	0.2516 mL	0.6291 mL

Fmoc-Cit-OH Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fmoc-Cit-OH133174-15-9Fmoc-L-CitrullineAmino Acid DerivativesProtecting groupspeptide synthesisderivativesamino acidsInhibitorinhibitorinhibit

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