Fmoc-His(3-Me)-OH

Cat. No.: HY-W111226: FAQs
Data Sheet SDS COA Handling Instructions

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Fmoc-His(3-Me)OH derives Histidine-associating compounds with biological activity. Fmoc-His(3-Me)OH, with Fmoc-citrulline-OH, Fmoc-His(1-Me)-OH together, forms tri-peptides and shows vasodilating effect with EC₅₀s of 2.7-4.7 mM in 1.0 mM Phenylephrine (PE)-contracted aorta rings. Fmoc-His(3-Me)OH (resin) also makes Methyl-His-Gly-Lys (His(3-Me)-Gly-Lys), thus acts as an [Ca²⁺]_i inhibitor. Fmoc-His(3-Me)OH methylates NAHIS02, making it unable to block the Alzheimer's Aβ channel.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Fmoc-His(3-Me)-OH Chemical Structure

CAS No. : 252049-16-4

Size	Price	Stock
100 mg	USD 53	Ask For Quote & Lead Time
250 mg	USD 73	Ask For Quote & Lead Time
1 g	USD 150	Ask For Quote & Lead Time

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Description

Molecular Weight

391.42

Formula

C₂₂H₂₁N₃O₄

CAS No.

252049-16-4

Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Purity: ≥98.0%

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Data Sheet (272 KB) SDS (393 KB)

COA (255 KB) HNMR (134 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Tanaka M, et al. His-Arg-Trp potently attenuates contracted tension of thoracic aorta of Sprague-Dawley rats through the suppression of extracellular Ca2+ influx. Peptides. 2009 Aug;30(8):1502-7. [Content Brief]

[2]. Kumrungsee T, et al. Identification of peptides from soybean protein, glycinin, possessing suppression of intracellular Ca2+ concentration in vascular smooth muscle cells. Food Chem. 2014;152:218-24. [Content Brief]

[3]. Arispe N, et al. Efficiency of histidine-associating compounds for blocking the alzheimer's Abeta channel activity and cytotoxicity. Biophys J. 2008 Nov 15;95(10):4879-89. [Content Brief]

Fmoc-His(3-Me)-OH Related Classifications

Cardiovascular Disease

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fmoc-His(3-Me)-OH252049-16-4Amino Acid DerivativesAmyloid-ββ-amyloid peptideAβAbetacardiovascular diseasesHistidine-Associating CompoundsAβ Channel ActivityAlzheimerFmoc-citrulline-OHFmoc-His(1-Me)-OHresin[Ca2+]iInhibitorinhibitorinhibit

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