2. PROTAC
  3. PROTAC Linkers
  4. Fmoc-N-PEG24-acid

Fmoc-N-PEG24-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Fmoc-N-PEG24-acid Chemical Structure

Fmoc-N-PEG24-acid Chemical Structure

CAS No. : 2170484-59-8

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Fmoc-N-PEG24-acid Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

Fmoc-N-PEG24-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fmoc-N-PEG24-acid Related Antibodies
Molecular Weight

1368.59

Formula

C66H113NO28
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O)OCC1C(C=CC=C2)=C2C3=C1C=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (73.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7307 mL 3.6534 mL 7.3068 mL
5 mM 0.1461 mL 0.7307 mL 1.4614 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.91%

COA (253 KB) HNMR (344 KB) LCMS (97 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.7307 mL 3.6534 mL 7.3068 mL 18.2670 mL
5 mM 0.1461 mL 0.7307 mL 1.4614 mL 3.6534 mL
10 mM 0.0731 mL 0.3653 mL 0.7307 mL 1.8267 mL
15 mM 0.0487 mL 0.2436 mL 0.4871 mL 1.2178 mL
20 mM 0.0365 mL 0.1827 mL 0.3653 mL 0.9133 mL
25 mM 0.0292 mL 0.1461 mL 0.2923 mL 0.7307 mL
30 mM 0.0244 mL 0.1218 mL 0.2436 mL 0.6089 mL
40 mM 0.0183 mL 0.0913 mL 0.1827 mL 0.4567 mL
50 mM 0.0146 mL 0.0731 mL 0.1461 mL 0.3653 mL
60 mM 0.0122 mL 0.0609 mL 0.1218 mL 0.3044 mL
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Fmoc-N-PEG24-acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fmoc-N-PEG24-acid2170484-59-8PROTAC LinkersInhibitorinhibitorinhibit

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