Fmoc-NH-ethyl-SS-propionic acid

Name: Fmoc-NH-ethyl-SS-propionic acid
Brand: MedChemExpress
SKU: HY-140118
Rating: 4.5 (1 reviews)

Cat. No.: HY-140118 Purity: 99.53%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

Fmoc-NH-ethyl-SS-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Fmoc-NH-ethyl-SS-propionic acid Chemical Structure

CAS No. : 864235-83-6

Size	Stock	Quantity
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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•Related Small Molecules:

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View All Isoforms

Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

Biological Activity
Purity & Documentation
References
Customer Review

Description

Fmoc-NH-ethyl-SS-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1].

IC₅₀ & Target

Disulfide Cleavable Linker

Cleavable Linker

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

403.52

Formula

C₂₀H₂₁NO₄S₂

CAS No.

864235-83-6

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CCSSCCNC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 29.17 mg/mL (72.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4782 mL	12.3910 mL	24.7819 mL
5 mM	0.4956 mL	2.4782 mL	4.9564 mL
10 mM	0.2478 mL	1.2391 mL	2.4782 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

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Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.53%

Select Batch:

Data Sheet (269 KB) SDS (393 KB)

COA (246 KB) HNMR (249 KB) RP-HPLC (192 KB) LCMS (98 KB)

Handling Instructions (2659 KB)

References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4782 mL	12.3910 mL	24.7819 mL	61.9548 mL
	5 mM	0.4956 mL	2.4782 mL	4.9564 mL	12.3910 mL
	10 mM	0.2478 mL	1.2391 mL	2.4782 mL	6.1955 mL
	15 mM	0.1652 mL	0.8261 mL	1.6521 mL	4.1303 mL
	20 mM	0.1239 mL	0.6195 mL	1.2391 mL	3.0977 mL
	25 mM	0.0991 mL	0.4956 mL	0.9913 mL	2.4782 mL
	30 mM	0.0826 mL	0.4130 mL	0.8261 mL	2.0652 mL
	40 mM	0.0620 mL	0.3098 mL	0.6195 mL	1.5489 mL
	50 mM	0.0496 mL	0.2478 mL	0.4956 mL	1.2391 mL
	60 mM	0.0413 mL	0.2065 mL	0.4130 mL	1.0326 mL