Fmoc-NH-PEG8-NHS ester

Name: Fmoc-NH-PEG8-NHS ester
Brand: MedChemExpress
SKU: HY-126880
Rating: 4.5 (1 reviews)

Cat. No.: HY-126880 Purity: ≥95.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Fmoc-NH-PEG8-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Fmoc-NH-PEG8-NHS ester Chemical Structure

CAS No. : 1334170-03-4

Size	Price	Stock	Quantity
25 mg	USD 45	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 68	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 102	In-stock	Estimated Time of Arrival: December 31
250 mg	USD 141	In-stock	Estimated Time of Arrival: December 31
1 g	USD 347	In-stock	Estimated Time of Arrival: December 31
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10 g		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

Biological Activity
Purity & Documentation
References
Customer Review

Description

Fmoc-NH-PEG8-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target

PEGs	Alkyl/ether

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

760.82

Formula

C₃₈H₅₂N₂O₁₄

CAS No.

1334170-03-4

Appearance

Liquid (Density: 1.28±0.1 g/cm³)

Color

Colorless to light yellow

SMILES

O=C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)NCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON4C(CCC4=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (131.44 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3144 mL	6.5719 mL	13.1437 mL
5 mM	0.2629 mL	1.3144 mL	2.6287 mL
10 mM	0.1314 mL	0.6572 mL	1.3144 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥95.0%

Select Batch:

Data Sheet (277 KB) SDS (393 KB)

COA (258 KB) HNMR (136 KB) LCMS (98 KB)

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.3144 mL	6.5719 mL	13.1437 mL	32.8593 mL
	5 mM	0.2629 mL	1.3144 mL	2.6287 mL	6.5719 mL
	10 mM	0.1314 mL	0.6572 mL	1.3144 mL	3.2859 mL
	15 mM	0.0876 mL	0.4381 mL	0.8762 mL	2.1906 mL
	20 mM	0.0657 mL	0.3286 mL	0.6572 mL	1.6430 mL
	25 mM	0.0526 mL	0.2629 mL	0.5257 mL	1.3144 mL
	30 mM	0.0438 mL	0.2191 mL	0.4381 mL	1.0953 mL
	40 mM	0.0329 mL	0.1643 mL	0.3286 mL	0.8215 mL
	50 mM	0.0263 mL	0.1314 mL	0.2629 mL	0.6572 mL
	60 mM	0.0219 mL	0.1095 mL	0.2191 mL	0.5477 mL
	80 mM	0.0164 mL	0.0821 mL	0.1643 mL	0.4107 mL
	100 mM	0.0131 mL	0.0657 mL	0.1314 mL	0.3286 mL