2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. Fmoc-PEA

Fmoc-PEA (Example 1-2) is a used as a cleavable linker for antibody-drug conjugates (ADC).

For research use only. We do not sell to patients.

Fmoc-PEA Chemical Structure

Fmoc-PEA Chemical Structure

CAS No. : 329223-23-6

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Based on 1 publication(s) in Google Scholar

Fmoc-PEA Related Antibodies

Top Publications Citing Use of Products

View All ADC Linker Isoform Specific Products:

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Fmoc-PEA (Example 1-2) is a used as a cleavable linker for antibody-drug conjugates (ADC)[1].

IC50 & Target[1]

Phosphatase Cleavable Linker

 

Cleavable Linker

 

Molecular Weight

363.30

Formula

C17H18NO6P
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)NCCOP(O)(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (550.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7525 mL 13.7627 mL 27.5255 mL
5 mM 0.5505 mL 2.7525 mL 5.5051 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.47%

SDS (393 KB)

COA (249 KB) HNMR (132 KB) RP-HPLC (234 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7525 mL 13.7627 mL 27.5255 mL 68.8137 mL
5 mM 0.5505 mL 2.7525 mL 5.5051 mL 13.7627 mL
10 mM 0.2753 mL 1.3763 mL 2.7525 mL 6.8814 mL
15 mM 0.1835 mL 0.9175 mL 1.8350 mL 4.5876 mL
20 mM 0.1376 mL 0.6881 mL 1.3763 mL 3.4407 mL
25 mM 0.1101 mL 0.5505 mL 1.1010 mL 2.7525 mL
30 mM 0.0918 mL 0.4588 mL 0.9175 mL 2.2938 mL
40 mM 0.0688 mL 0.3441 mL 0.6881 mL 1.7203 mL
50 mM 0.0551 mL 0.2753 mL 0.5505 mL 1.3763 mL
60 mM 0.0459 mL 0.2294 mL 0.4588 mL 1.1469 mL
80 mM 0.0344 mL 0.1720 mL 0.3441 mL 0.8602 mL
100 mM 0.0275 mL 0.1376 mL 0.2753 mL 0.6881 mL
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Fmoc-PEA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fmoc-PEA329223-23-6ADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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