Fmoc-PEG4-NHS ester

Name: Fmoc-PEG4-NHS ester
Brand: MedChemExpress
SKU: HY-122456
Rating: 4.5 (1 reviews)

Cat. No.: HY-122456 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Fmoc-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Fmoc-PEG4-NHS ester Chemical Structure

CAS No. : 1314378-14-7

Size	Price	Stock	Quantity
250 mg	USD 31	In-stock	Estimated Time of Arrival: December 31
1 g	USD 92	In-stock	Estimated Time of Arrival: December 31
5 g		Get quote
10 g		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

Biological Activity
Purity & Documentation
References
Customer Review

Description

Fmoc-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target

PEGs	Alkyl/ether

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

584.61

Formula

C₃₀H₃₆N₂O₁₀

CAS No.

1314378-14-7

Appearance

Viscous Liquid

Color

Colorless to light yellow

SMILES

O=C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)NCCOCCOCCOCCOCCC(ON4C(CCC4=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (171.05 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7105 mL	8.5527 mL	17.1054 mL
5 mM	0.3421 mL	1.7105 mL	3.4211 mL
10 mM	0.1711 mL	0.8553 mL	1.7105 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (268 KB) SDS (393 KB)

COA (244 KB) HNMR (133 KB)

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7105 mL	8.5527 mL	17.1054 mL	42.7636 mL
	5 mM	0.3421 mL	1.7105 mL	3.4211 mL	8.5527 mL
	10 mM	0.1711 mL	0.8553 mL	1.7105 mL	4.2764 mL
	15 mM	0.1140 mL	0.5702 mL	1.1404 mL	2.8509 mL
	20 mM	0.0855 mL	0.4276 mL	0.8553 mL	2.1382 mL
	25 mM	0.0684 mL	0.3421 mL	0.6842 mL	1.7105 mL
	30 mM	0.0570 mL	0.2851 mL	0.5702 mL	1.4255 mL
	40 mM	0.0428 mL	0.2138 mL	0.4276 mL	1.0691 mL
	50 mM	0.0342 mL	0.1711 mL	0.3421 mL	0.8553 mL
	60 mM	0.0285 mL	0.1425 mL	0.2851 mL	0.7127 mL
	80 mM	0.0214 mL	0.1069 mL	0.2138 mL	0.5345 mL
	100 mM	0.0171 mL	0.0855 mL	0.1711 mL	0.4276 mL