Fmoc-VAP-MMAE

Cat. No.: HY-148339: FAQs
Data Sheet Handling Instructions

Molarity Calculator

Fmoc-VAP-MMAE is a agent-linker conjugates for ADC. Fmoc-VAP-MMAE consists of an ADC linker and a tubulin inhibitor MMAE (HY-15162), with a protective Fmoc group.

For research use only. We do not sell to patients.

Fmoc-VAP-MMAE Chemical Structure

CAS No. : 1912408-91-3

Size	Price	Stock
5 mg	USD 230	Ask For Quote & Lead Time
10 mg	USD 375	Ask For Quote & Lead Time
25 mg	USD 780	Ask For Quote & Lead Time
50 mg	USD 1250	Ask For Quote & Lead Time
100 mg	USD 2000	Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Fmoc-VAP-MMAE is a agent-linker conjugates for ADC. Fmoc-VAP-MMAE consists of an ADC linker and a tubulin inhibitor MMAE (HY-15162), with a protective Fmoc group^[1].

Molecular Weight

1259.57

Formula

C₇₀H₉₈N₈O₁₃

CAS No.

1912408-91-3

Appearance

Solid

Color

White to off-white

SMILES

O=C(N1[C@](CCC1)([H])[C@H](OC)[C@@H](C)C(N[C@H](C)[C@H](C2=CC=CC=C2)O)=O)C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC(C=C3)=CC=C3NC([C@H](C)NC([C@H](C(C)C)NC(OCC4C5=CC=CC=C5C6=CC=CC=C64)=O)=O)=O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 75 mg/mL (59.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.7939 mL	3.9696 mL	7.9392 mL
5 mM	0.1588 mL	0.7939 mL	1.5878 mL
10 mM	0.0794 mL	0.3970 mL	0.7939 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Jackson David Y et al. Novel antibody-drug conjugates and related compounds, compositions, and methods of use. Patent. WO2016064749.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.7939 mL	3.9696 mL	7.9392 mL	19.8480 mL
	5 mM	0.1588 mL	0.7939 mL	1.5878 mL	3.9696 mL
	10 mM	0.0794 mL	0.3970 mL	0.7939 mL	1.9848 mL
	15 mM	0.0529 mL	0.2646 mL	0.5293 mL	1.3232 mL
	20 mM	0.0397 mL	0.1985 mL	0.3970 mL	0.9924 mL
	25 mM	0.0318 mL	0.1588 mL	0.3176 mL	0.7939 mL
	30 mM	0.0265 mL	0.1323 mL	0.2646 mL	0.6616 mL
	40 mM	0.0198 mL	0.0992 mL	0.1985 mL	0.4962 mL
	50 mM	0.0159 mL	0.0794 mL	0.1588 mL	0.3970 mL

Fmoc-VAP-MMAE Related Classifications

Others

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fmoc-VAP-MMAE1912408-91-3Drug-Linker Conjugates for ADCADCFmocDrug-linkertubulinInhibitorinhibitorinhibit

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