Folate-PEG3-amine

Name: Folate-PEG3-amine
Brand: MedChemExpress
SKU: HY-138484
Rating: 4.5 (1 reviews)

Cat. No.: HY-138484 Purity: 99.69%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

Folate-PEG3-amine is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Folate-PEG3-amine Chemical Structure

CAS No. : 710323-40-3

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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•Related Small Molecules:

•Related Proteins:

View All ADC Linker Isoform Specific Products:

View All Isoforms

Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

Biological Activity
Purity & Documentation
References
Customer Review

Description

Folate-PEG3-amine is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1].

IC₅₀ & Target

Cleavable Linker

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

615.64

Formula

C₂₇H₃₇N₉O₈

CAS No.

710323-40-3

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(O)[C@@H](NC(C1=CC=C(NCC2=CN=C3NC(N)=NC(C3=N2)=O)C=C1)=O)CCC(NCCOCCOCCOCCN)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (162.43 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6243 mL	8.1216 mL	16.2433 mL
5 mM	0.3249 mL	1.6243 mL	3.2487 mL
10 mM	0.1624 mL	0.8122 mL	1.6243 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.69%

Select Batch:

Data Sheet (266 KB) SDS (393 KB)

COA (242 KB) HNMR (530 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6243 mL	8.1216 mL	16.2433 mL	40.6081 mL
	5 mM	0.3249 mL	1.6243 mL	3.2487 mL	8.1216 mL
	10 mM	0.1624 mL	0.8122 mL	1.6243 mL	4.0608 mL
	15 mM	0.1083 mL	0.5414 mL	1.0829 mL	2.7072 mL
	20 mM	0.0812 mL	0.4061 mL	0.8122 mL	2.0304 mL
	25 mM	0.0650 mL	0.3249 mL	0.6497 mL	1.6243 mL
	30 mM	0.0541 mL	0.2707 mL	0.5414 mL	1.3536 mL
	40 mM	0.0406 mL	0.2030 mL	0.4061 mL	1.0152 mL
	50 mM	0.0325 mL	0.1624 mL	0.3249 mL	0.8122 mL
	60 mM	0.0271 mL	0.1354 mL	0.2707 mL	0.6768 mL
	80 mM	0.0203 mL	0.1015 mL	0.2030 mL	0.5076 mL
	100 mM	0.0162 mL	0.0812 mL	0.1624 mL	0.4061 mL