2. PROTAC Immunology/Inflammation
  3. PROTACs AP-1
  4. FOSL1 degrader 1

FOSL1 degrader 1 (4) is a T-5224-PROTAC, potently degrade FOSL1 (AP-1) to suppress cancer stemness gene expression in HNSCC. FOSL1 degrader 1 (4) effectively eliminate HNSCC cancer stem cells to inhibit tumor growth through degrading FOSL1. FOSL1 degrader 1 (4) displays around 30- to 100-fold increased potency over T-5224 (Pink: T-5224 (HY-12270); Black: Linker (HY-130200); Blue: Pomalidomide (HY-10984)).

For research use only. We do not sell to patients.

FOSL1 degrader 1 Chemical Structure

FOSL1 degrader 1 Chemical Structure

Size Price Stock
5 mg USD 790 Ask For Quote & Lead Time
10 mg USD 1265 Ask For Quote & Lead Time
25 mg USD 2656 Ask For Quote & Lead Time

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

FOSL1 degrader 1 Related Antibodies

Top Publications Citing Use of Products

View All PROTACs Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

View All AP-1 Isoform Specific Products:

View All Isoforms
c-Fos c-Jun

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

FOSL1 degrader 1 (4) is a T-5224-PROTAC, potently degrade FOSL1 (AP-1) to suppress cancer stemness gene expression in HNSCC. FOSL1 degrader 1 (4) effectively eliminate HNSCC cancer stem cells to inhibit tumor growth through degrading FOSL1. FOSL1 degrader 1 (4) displays around 30- to 100-fold increased potency over T-5224 (Pink: T-5224 (HY-12270); Black: Linker (HY-130200); Blue: Pomalidomide (HY-10984))[1].

Molecular Weight

1124.19

Formula

C58H69N5O18
Appearance

Solid

Color

White to yellow

SMILES

O=C1CCC(N2C(C(C(NCCOCCOCCOCCOCCOCCOCCOCCNC(CCC3=C(OCC4=CC(ON=C5O)=C5C=C4)C=CC(C(C6=C(O)C=C(OC7CCCC7)C=C6)=O)=C3)=O)=CC=C8)=C8C2=O)=O)C(N1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (88.95 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8895 mL 4.4476 mL 8.8953 mL
5 mM 0.1779 mL 0.8895 mL 1.7791 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8895 mL 4.4476 mL 8.8953 mL 22.2382 mL
5 mM 0.1779 mL 0.8895 mL 1.7791 mL 4.4476 mL
10 mM 0.0890 mL 0.4448 mL 0.8895 mL 2.2238 mL
15 mM 0.0593 mL 0.2965 mL 0.5930 mL 1.4825 mL
20 mM 0.0445 mL 0.2224 mL 0.4448 mL 1.1119 mL
25 mM 0.0356 mL 0.1779 mL 0.3558 mL 0.8895 mL
30 mM 0.0297 mL 0.1483 mL 0.2965 mL 0.7413 mL
40 mM 0.0222 mL 0.1112 mL 0.2224 mL 0.5560 mL
50 mM 0.0178 mL 0.0890 mL 0.1779 mL 0.4448 mL
60 mM 0.0148 mL 0.0741 mL 0.1483 mL 0.3706 mL
80 mM 0.0111 mL 0.0556 mL 0.1112 mL 0.2780 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

FOSL1 degrader 1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FOSL1 degrader 1PROTACsAP-1Activator Protein 1PROTACFOSL1HNSCCcancer stem cellInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
FOSL1 degrader 1
Cat. No.:
HY-162723
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.