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  5. FRETS-VWF73

FRETS-VWF73 is a biological active peptide. (FRETS-VWF73 is a very powerful Fluorescence-Quenching Substrate for the VWF cleaving protease ADAMTS-13. It is commonly used as a useful tool for the rapid measurement of ADAMTS-13 activity in plasma and is a predictive marker for various thrombotic diseases like TPP. Our new substrate FRETS-VWF73 can be easily used with a 96-well format in commercial plate readers.)

For research use only. We do not sell to patients.

FRETS-VWF73 Chemical Structure

FRETS-VWF73 Chemical Structure

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Description

FRETS-VWF73 is a biological active peptide. (FRETS-VWF73 is a very powerful Fluorescence-Quenching Substrate for the VWF cleaving protease ADAMTS-13. It is commonly used as a useful tool for the rapid measurement of ADAMTS-13 activity in plasma and is a predictive marker for various thrombotic diseases like TPP. Our new substrate FRETS-VWF73 can be easily used with a 96-well format in commercial plate readers.)

Molecular Weight

8314.28

Formula

C370H583N103O113S

Sequence

H-Asp-Arg-Glu-{Dap(Nma)}-Ala-Pro-Asn-Leu-Val-Tyr-Met-Val-Thr-Gly-{Dap(Dnp)}-Pro-Ala-Ser-Asp-Glu-Ile-Lys-Arg-Leu-Pro-Gly-Asp-Ile-Gln-Val-Val-Pro-Ile-Gly-Val-Gly-Pro-Asn-Ala-Asn-Val-Gln-Glu-Leu-Glu-Arg-Ile-Gly-Trp-Pro-Asn-Ala-Pro-Ile-Leu-Ile-Gln-Asp-Phe-Glu-Thr-Leu-Pro-Arg-Glu-Ala-Pro-Asp-Leu-Val-Leu-Gln-Arg-OH

Sequence Shortening

DRE-{Dap(Nma)}-APNLVYMVTG-{Dap(Dnp)}-PASDEIKRLPGDIQVVPIGVGPNANVQELERIGWPNAPILIQDFETLPREAPDLVLQR

SMILES

O=C([C@@H](N)CC(O)=O)N[C@H](C(N[C@H](C(N[C@@H](CNC(C1=CC=CC=C1NC)=O)C(N[C@H](C(N2[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CNC3=CC=C([N+]([O-])=O)C=C3[N+]([O-])=O)C(N4[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N5[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N6[C@H](C(N[C@H](C(NCC(N[C@H](C(NCC(N7[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N8[C@H](C(N[C@H](C(N[C@H](C(N9[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N%10[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N%11[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CC(C)C)=O)C(C)C)=O)CC(C)C)=O)CC(O)=O)=O)CCC%11)=O)C)=O)CCC(O)=O)=O)CCCNC(N)=N)=O)CCC%10)=O)CC(C)C)=O)[C@@H](C)O)=O)CCC(O)=O)=O)CC%12=CC=CC=C%12)=O)CC(O)=O)=O)CCC(N)=O)=O)[C@H](CC)C)=O)CC(C)C)=O)[C@H](CC)C)=O)CCC9)=O)C)=O)CC(N)=O)=O)CCC8)=O)CC%13=CNC%14=CC=CC=C%13%14)=O)=O)[C@H](CC)C)=O)CCCNC(N)=N)=O)CCC(O)=O)=O)CC(C)C)=O)CCC(O)=O)=O)CCC(N)=O)=O)C(C)C)=O)CC(N)=O)=O)C)=O)CC(N)=O)=O)CCC7)=O)=O)C(C)C)=O)=O)[C@H](CC)C)=O)CCC6)=O)C(C)C)=O)C(C)C)=O)CCC(N)=O)=O)[C@H](CC)C)=O)CC(O)=O)=O)=O)CCC5)=O)CC(C)C)=O)CCCNC(N)=N)=O)CCCCN)=O)[C@H](CC)C)=O)CCC(O)=O)=O)CC(O)=O)=O)CO)=O)C)=O)CCC4)=O)=O)=O)[C@@H](C)O)=O)C(C)C)=O)CCSC)=O)CC%15=CC=C(O)C=C%15)=O)C(C)C)=O)CC(C)C)=O)CC(N)=O)=O)CCC2)=O)C)=O)=O)CCC(O)=O)=O)CCCNC(N)=N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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FRETS-VWF73
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HY-P5354
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